@article{3142172,
    title = "The Association between Diet and Serum Concentrations of IGF-I, IGFBP-1,
IGFBP-2, and IGFBP-3 in the European Prospective Investigation into
Cancer and Nutrition",
    author = "Crowe, Francesca L. and Key, Timothy J. and Allen, Naomi E. and Appleby, and Paul N. and Roddam, Andrew and Overvad, Kim and Gronbaek, Henning and and Tjonneland, Anne and Halkjaer, Jutte and Dossus, Laure and Boeing, and Heiner and Kroeger, Janine and Trichopoulou, Antonia and Dilis, Vardis and and Trichopoulos, Dimitrios and Boutron-Ruault, Marie-Christine and De and Lauzon, Blandine and Clavel-Chapelon, Francoise and Palli, Domenico and and Berrino, Franco and Panico, Salvatore and Tumino, Rosario and Sacerdote, and Carlotta and Bueno-de-Mesquita, H. Bas and Vrieling, Alina and van Gils, and Carla H. and Peeters, Petra H. M. and Gram, Inger T. and Skeie, Guri and and Lund, Eiliv and Rodriguez, Laudina and Jakszyn, Paula and Molina-Montes, and Esther and Tormo, Maria J. and Barricarte, Aurelio and Larranaga, Nerea and and Khaw, Kay-Tee and Bingham, Sheila and Rinaldi, Sabina and Slimani, and Nadia and Norat, Teresa and Gallo, Valentina and Riboli, Elio and Kaaks, and Rudolf",
    journal = "Cancer Epidemiology, Biomarkers & Prevention",
    year = "2009",
    volume = "18",
    number = "5",
    pages = "1333-1340",
    publisher = "AMER ASSOC CANCER RESEARCH",
    issn = "1055-9965, 1538-7755",
    doi = "10.1158/1055-9965.EPI-08-0781",
    abstract = "Circulating concentrations of insulin-like growth factor I (IGF-I) and
IGF binding proteins (IGFBP) have been associated with the risk of
several types of cancer. Dietary correlates of IGF-I and IGFBPs are not
yet well established. The objective of this study was to assess the
association between dietary intake and serum concentrations of IGF-I,
IGFBP-1, IGFBP-2, and IGFBP-3 in a cross-sectional analysis of 4,731 men
and women taking part in the European Prospective Investigation into
Cancer and Nutrition. Diet was assessed using country-specific validated
dietary questionnaires. Serum concentrations of IGF-I, IGFBP-1, IGFBP-2
and IGFBP-3 were measured, and the associations between diet and IGF-I
and IGFBPs were assessed using multiple linear regression adjusting for
sex, age, body mass index, smoking status, and alcohol and energy
intake. Each I SD increment increase in total and dairy protein and
calcium intake was associated with an increase in IGF-I concentration of
2.5%, 2.4%, and 3.3%, respectively (P for trend <0.001 for all) and a
decrease in IGFBP-2 of 3.5%, 3.5%, and 5.4% (P for trend <0.001 for
all), respectively. There were no significant associations between the
intake of protein or calcium from nondairy sources and IGF-I. The
results from this large cross-sectional analysis show that either the
intake of dairy protein or calcium is an important dietary determinant
of IGF-I and IGFBP-2 concentrations; however, we suggest that it is more
likely to be protein from dairy products. (Cancer Epidemiol Biomarkers
Prev 2009;18(5):1333-40)"
}