@incollection{3144475,
    title = "Exhaled breath condensate: hydrogen peroxide",
    author = "Loukides, S. and Bakakos, P. and Kostikas, K.",
    booktitle = "EXHALED BIOMARKERS",
    publisher = "European Respiratory Society",
    year = "2010",
    isbn = "978-1-84984-005-7",
    pages = "162-172",
    doi = "10.1183/1025448x.00019009",
    keywords = "Exhaled breath condensate; hydrogen peroxide; lung diseases; oxidative
stress",
    abstract = "The lung is susceptible to oxidative injury in the form of several
reactive oxygen species, including hydrogen peroxide (H2O2). The main
cellular sources for H2O2 are neutrophils, eosinophils, alveolar
macrophages, epithelial cells and endothelial cells.
H2O2 has been extensively studied in exhaled breath condensate (EBC)
incorporating various techniques, including the onsite measurement with
an automated amperometric biosensor.
EBC H2O2 has been measured in various diseases, mainly in asthma and
chronic obstructive pulmonary disease, with most of the clinical studies
reporting higher levels compared to normal subjects. Associations of EBC
H2O2 levels with parameters obtained from other biological fluids, such
as bronchoalveolar lavage and induced sputum have been reported. These
findings are interpreted in the context of increased oxidative stress in
various lung inflammatory diseases. Results related to treatment
intervention lack validity, since they are mainly designed in an
uncontrolled manner.
In conclusion, the usefulness of H2O2 in clinical research and practice
is limited, despite the fact that it offers the possibility to be
measured in the field, mainly due to methodological issues."
}