@article{3145200,
    title = "Polymorphisms in fatty acid metabolism-related genes are associated with
colorectal cancer risk",
    author = "Hoeft, Birgit and Linseisen, Jakob and Beckmann, Lars and and Mueller-Decker, Karin and Canzian, Federico and Huesing, Anika and and Kaaks, Rudolf and Vogel, Ulla and Jakobsen, Marianne U. and Overvad, Kim and and Hansen, Rikke D. and Knueppel, Sven and Boeing, Heiner and and Trichopoulou, Antonia and Koumantaki, Yvoni and Trichopoulos, Dimitrios and and Berrino, Franco and Palli, Domenico and Panico, Salvatore and and Tumino, Rosario and Bueno-de-Mesquita, H. B. and van Duijnhoven, Franzel and J. B. and van Gils, Carla H. and Peeters, Petra H. and Dumeaux, Vanessa and and Lund, Eiliv and Huerta Castano, Jose M. and Munoz, Xavier and and Rodriguez, Laudina and Barricarte, Aurelio and Manjer, Jonas and and Jirstrom, Karin and Van Guelpen, Bethany and Hallmans, Goran and and Spencer, Elizabeth A. and Crowe, Francesca L. and Khaw, Kay-Tee and and Wareham, Nick and Morois, Sophie and Boutron-Ruault, Marie-Christine and and Clavel-Chapelon, Francoise and Chajes, Veronique and Jenab, Mazda and and Boffetta, Paolo and Vineis, Paolo and Mouw, Traci and Norat, Teresa and and Riboli, Elio and Nieters, Alexandra",
    journal = "Journal of Carcinogenesis",
    year = "2010",
    volume = "31",
    number = "3",
    pages = "466-472",
    publisher = "Oxford University Press",
    issn = "1477-3163",
    doi = "10.1093/carcin/bgp325",
    abstract = "Colorectal cancer (CRC) is the third most common malignant tumor and the
fourth leading cause of cancer death worldwide. The crucial role of
fatty acids for a number of important biological processes suggests a
more in-depth analysis of inter-individual differences in fatty acid
metabolizing genes as contributing factor to colon carcinogenesis. We
examined the association between genetic variability in 43 fatty acid
metabolism-related genes and colorectal risk in 1225 CRC cases and 2032
controls participating in the European Prospective Investigation into
Cancer and Nutrition study. Three hundred and ninety two
single-nucleotide polymorphisms were selected using pairwise tagging
with an r(2) cutoff of 0.8 and a minor allele frequency of > 5%.
Conditional logistic regression models were used to estimate odds ratios
and corresponding 95% confidence intervals. Haplotype analysis was
performed using a generalized linear model framework. On the genotype
level, hydroxyprostaglandin dehydrogenase 15-(NAD) (HPGD), phospholipase
A2 group VI (PLA2G6) and transient receptor potential vanilloid 3 were
associated with higher risk for CRC, whereas prostaglandin E receptor 2
(PTGER2) was associated with lower CRC risk. A significant inverse
association (P < 0.006) was found for PTGER2 GGG haplotype, whereas HPGD
AGGAG and PLA2G3 CT haplotypes were significantly (P < 0.001 and P =
0.003, respectively) associated with higher risk of CRC. Based on these
data, we present for the first time the association of HPGD variants
with CRC risk. Our results support the key role of prostanoid signaling
in colon carcinogenesis and suggest a relevance of genetic variation in
fatty acid metabolism-related genes and CRC risk."
}