@article{3145600,
    title = "Dual-Energy X-Ray Absorptiometry and Quantitative Ultrasound in Patients
With Paget's Disease of Bone Before and After Treatment With Zoledronic
Acid: Association With Serum Bone Markers and Dickkopf-1",
    author = "Polyzos, Stergios A. and Anastasilakis, Athanasios D. and Litsas, and Ioannis and Sapranidis, Michail and Efstathiadou, Zoe and Kita, Marina and and Arsos, Georgios and Moralidis, Efstratios and Zafeiriadou, Efthimia and and Papatheodorou, Athanasios and Terpos, Evangelos",
    journal = "Journal of Clinical Densitometry",
    year = "2010",
    volume = "13",
    number = "2",
    pages = "190-196",
    publisher = "EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC",
    issn = "1094-6950",
    doi = "10.1016/j.jocd.2010.01.006",
    keywords = "Dickkopf-1; dual-energy X-ray absorptiometry; Paget’s disease of bone;
quantitative ultrasound; zoledronic acid",
    abstract = "The main aim of this study was to determine the effect of zoledronic
acid (ZOL) on parameters of dual-energy X-ray absorptiometry (DXA) and
quantitative ultrasound (QUS) in unaffected bones of patients with
Paget’s disease of bone (PDB). The secondary aim was the association of
bone markers and Dickkopf (DKK)-1 with parameters of DXA and QUS. Ten
consecutive patients with polyostotic PDB (median age: 63 yr) received a
single 5-mg ZOL infusion. The patients were subjected to calcaneal QUS
and DXA of both lumbar spine (LS) and femoral neck (FN). Blood samples
for serum bone markers and DKK-1 were serially obtained for 12 mo. There
was a significant increase in LS (p = 0.005) and FN bone mineral density
(BMD) (p = 0.021) 12 mo after ZOL infusion. QUS parameters remained
unaffected throughout the study. A significant correlation between
broadband ultrasound attenuation and DKK-1 (p < 0.001) and between speed
of sound and DKK-1 (p = 0.033) at baseline was found, which remained
significant after adjustment for gender, age, and body mass index. Our
data suggest that a single ZOL infusion significantly increases
nonpagetic BMD 12 mo after treatment but has no effect on QUS parameters
or DKK-1. Significant correlations were observed between QUS parameters
and DICK-1 at baseline."
}