@article{3145725,
    title = "Plasma Folate, Related Genetic Variants, and Colorectal Cancer Risk in
EPIC",
    author = "Eussen, Simone J. P. M. and Vollset, Stein Emil and Igland, Jannicke and and Meyer, Klaus and Fredriksen, Ase and Ueland, Per Magne and Jenab, Mazda and and Slimani, Nadia and Boffetta, Paolo and Overvad, Kim and Tjonneland, and Anne and Olsen, Anja and Clavel-Chapelon, Francoise and Boutron-Ruault, and Marie-Christine and Morois, Sophie and Weikert, Cornelia and Pischon, and Tobias and Linseisen, Jakob and Kaaks, Rudolf and Trichopoulou, Antonia and and Zilis, Demosthenes and Katsoulis, Michael and Palli, Domenico and and Berrino, Franco and Vineis, Paolo and Tumino, Rosario and Panico, and Salvatore and Peeters, Petra H. M. and Bueno-de-Mesquita, H. Bas and van and Duijnhoven, Franzel J. B. and Gram, Inger Torhild and Skeie, Guri and and Lund, Eiliv and Gonzalez, Carlos A. and Martinez, Carmen and Dorronsoro, and Miren and Ardanaz, Eva and Navarro, Carmen and Rodriguez, Laudina and and Van Guelpen, Bethany and Palmqvist, Richard and Manjer, Jonas and and Ericson, Ulrika and Bingham, Sheila and Khaw, Kay-Tee and Norat, Teresa and and Riboli, Elio",
    journal = "Cancer Epidemiology, Biomarkers & Prevention",
    year = "2010",
    volume = "19",
    number = "5",
    pages = "1328-1340",
    publisher = "AMER ASSOC CANCER RESEARCH",
    issn = "1055-9965, 1538-7755",
    doi = "10.1158/1055-9965.EPI-09-0841",
    abstract = "Background: A potential dual role of folate in colorectal cancer (CRC)
is currently subject to debate. We investigate the associations between
plasma folate, several relevant folate-related polymorphisms, and CRC
risk within the large European Prospective Investigation into Cancer and
Nutrition cohort.
Methods: In this nested case-control study, 1,367 incident CRC cases
were matched to 2,325 controls for study center, age, and sex. Risk
ratios (RR) were estimated with conditional logistic regression and
adjusted for smoking, education, physical activity, and intake of
alcohol and fiber.
Results: Overall analyses did not reveal associations of plasma folate
with CRC. The RR (95% confidence interval; P-trend) for the fifth
versus the first quintile of folate status was 0.94 (0.74-1.20; 0.44).
The polymorphisms MTHFR677C -> T, MTHFR1298A -> C, MTR2756A -> G,
MTRR66A -> G, and MTHFD11958G -> A were not associated with CRC risk.
However, in individuals with the lowest plasma folate concentrations,
the MTHFR 677TT genotype showed a statistically nonsignificant increased
CRC risk [RR (95% CI; P-trend) TT versus CC = 1.39 (0.87-2.21);
0.12], whereas those with the highest folate concentrations showed a
nonsignificant decreased CRC risk [RR TT versus CC = 0.74 (0.39-1.37);
0.34]. The SLC19A180G -> A showed a positive association with CRC risk
[RR AA versus GG 1.30 (1.06-1.59); <0.01].
Conclusions: This large European prospective multicenter study did not
show an association of CRC risk with plasma folate status nor with MTHFR
polymorphisms.
Impact: Findings of the present study tend to weaken the evidence that
folate plays an important role in CRC carcinogenesis. However, larger
sample sizes are needed to adequately address potential gene-environment
interactions. Cancer Epidemiol Biomarkers Prev; 19(5); 1328-40. (C)2010
AACR."
}