@article{3145885,
    title = "Anthropometric Measures, Body Mass Index, and Pancreatic Cancer A Pooled
Analysis From the Pancreatic Cancer Cohort Consortium (PanScan)",
    author = "Arslan, Alan A. and Helzlsouer, Kathy J. and Kooperberg, Charles and and Shu, Xiao-Ou and Steplowski, Emily and Bueno-de-Mesquita, H. Bas and and Fuchs, Charles S. and Gross, Myron D. and Jacobs, Eric J. and LaCroix, and Andrea Z. and Petersen, Gloria M. and Stolzenberg-Solomon, Rachael Z. and and Zheng, Wei and Albanes, Demetrius and Amundadottir, Laufey and and Bamlet, William R. and Barricarte, Aurelio and Bingham, Sheila A. and and Boeing, Heiner and Boutron-Ruault, Marie-Christine and Buring, Julie E. and and Chanock, Stephen J. and Clipp, Sandra and Gaziano, J. Michael and and Giovannucci, Edward L. and Hankinson, Susan E. and Hartge, Patricia and and Hoover, Robert N. and Hunter, David J. and Hutchinson, Amy and Jacobs, and Kevin B. and Kraft, Peter and Lynch, Shannon M. and Manjer, Jonas and and Manson, JoAnn E. and McTiernan, Anne and McWilliams, Robert R. and and Mendelsohn, Julie B. and Michaud, Dominique S. and Palli, Domenico and and Rohan, Thomas E. and Slimani, Nadia and Thomas, Gilles and Tjonneland, and Anne and Tobias, Geoffrey S. and Trichopoulos, Ditnitrios and Virtamo, and Jarmo and Wolpin, Brian M. and Yu, Kai and Zeleniuch-Jacquotte, Anne and and Patel, Alpa V.",
    journal = "Polish Archives of Internal Medicine",
    year = "2010",
    volume = "170",
    number = "9",
    pages = "791-802",
    publisher = "AMER MEDICAL ASSOC",
    doi = "10.1001/archinternmed.2010.63",
    abstract = "Background: Obesity has been proposed as a risk factor for pancreatic
cancer.
Methods: Pooled data were analyzed from the National Cancer Institute
Pancreatic Cancer Cohort Consortium (PanScan) to study the association,
between prediagnostic anthropometric measures and risk of pancreatic
cancer. PanScan applied a nested case-control study design and included
2170 cases and 2209 control subjects. Odds ratios (ORs) and 95%
confidence intervals (CIs) were estimated using unconditional logistic
regression for cohort-specific quartiles of body mass index (BMI
[calculated as weight in kilograms divided by height in meters
squared]), weight, height, waist circumference, and waist to hip ratio
as well as conventional BMI categories (underweight, <18.5; normal
weight, 18.5-24.9; overweight, 25.0-29.9; obese, 30.0-34.9; and severely
obese, >= 35.0). Models were adjusted for potential confounders.
Results: In all of the participants, a positive association between
increasing BMI and risk of pancreatic cancer was observed (adjusted OR
for the highest vs lowest BMI guartile, 1.33; 95% Cl, 1.12-1.58;
P-trend<.001). In men, the adjusted OR for pancreatic cancer for the
highest vs lowest quartile of BMI was 1.33 (95% Cl, 1.04-1.69;
P-trend<.03), and in women it was 1.34 (95% Cl, 1.05-1.70;
P-trend=.01). Increased waist to hip ratio was associated with increased
risk of pancreatic cancer in women (adjusted OR for the highest vs
lowest quartile, 1.87; 95% Cl, 1.31-2.69; P-trend=.003) but less so in
men.
Conclusions: These findings provide strong support for a positive
association between BMI and pancreatic cancer risk. In addition,
centralized fat distribution may increase pancreatic cancer risk,
especially in women. Arch Intern Med. 2010;170(9):791 -802"
}