@article{3145897,
    title = "Anthropometric measures and epithelial ovarian cancer risk in the
European Prospective Investigation into Cancer and Nutrition",
    author = "Lahmann, Petra H. and Cust, Anne E. and Friedenreich, Christine M. and and Schulz, Mandy and Lukanova, Annekatrin and Kaaks, Rudolf and Lundin, Eva and and Tjonneland, Anne and Halkjaer, Jytte and Severinsen, Marianne Tang and and Overvad, Kim and Fournier, Agnes and Chabbert-Buffet, Nathalie and and Clavel-Chapelon, Francoise and Dossus, Laure and Pischon, Tobias and and Boeing, Heiner and Trichopoulou, Antonia and Lagiou, Pagona and Naska, and Androniki and Palli, Domenico and Grioni, Sara and Mattiello, Amalia and and Tumino, Rosario and Sacerdote, Carlotta and Redondo, Maria-Luisa and and Jakszyn, Paula and Sanchez, Maria-Jose and Tormo, Maria-Jose and and Ardanaz, Eva and Arriola, Larraitz and Manjer, Jonas and Jirstrom, Karin and and Bueno-de-Mesquita, H. Bas and May, Anne M. and Peeters, Petra H. M. and and Onland-Moret, N. Charlotte and Bingham, Sheila and Khaw, Kay-Tee and and Allen, Naomi E. and Spencer, Elizabeth and Rinaldi, Sabina and Slimani, and Nadia and Chajes, Veronique and Michaud, Dominique and Norat, Teresa and and Riboli, Elio",
    journal = "International Journal  of Cancer",
    year = "2010",
    volume = "126",
    number = "10",
    pages = "2404-2415",
    publisher = "Wiley",
    issn = "0020-7136",
    doi = "10.1002/ijc.24952",
    keywords = "anthropometry; ovarian cancer; etiology; obesity; menopausal status",
    abstract = "We examined the associations of measured anthropometric factors,
including general and central adiposity and height, with ovarian cancer
risk. We also investigated these associations by menopausal status and
for specific histological subtypes. Among 226,798 women in the European
Prospective Investigation into Cancer and Nutrition (EPIC) cohort, there
were 611 incident cases of primary, malignant, epithelial ovarian cancer
diagnosed during a mean 8.9 years of follow-up. Cox proportional hazards
models were used to estimate hazard ratios (HRs) and 95% confidence
intervals (as), adjusted for potential confounders. Compared to women
with body mass index (BMI) < 25 kg/m(2), obesity (BMI >= 30 kg/m(2)) was
associated with excess ovarian cancer risk for all women combined (HR =
1.33, 95% Cl = 1.05-1.68; p(trend) = 0.02) and postmenopausal women (HR
= 1.59, 95% Cl = 1.20-2.10; p(trend) = 0.001), but the association was
weaker for premenopausal women (HR = 1.16, 95% Cl = 0.65-2.06; p(trend)
= 0.65). Neither height or weight gain, nor BMI-adjusted measures of fat
distribution assessed by waist circumference, waist-hip ratio (WHR) or
hip circumference were associated with overall risk. WHR was related to
increased risk of mucinous tumors (BMI-adjusted HR per 0.05 unit
increment = 1.17, 95% Cl = 1.00-1.38). For all women combined, no other
significant associations with risk were observed for specific
histological subtypes. This large, prospective study provides evidence
that obesity is an important modifiable risk factor for epithelial
ovarian cancer, particularly among postmenopausal women."
}