@article{3147469,
    title = "A multi-stage genome-wide association study of bladder cancer identifies
multiple susceptibility loci",
    author = "Rothman, Nathaniel and Garcia-Closas, Montserrat and Chatterjee, and Nilanjan and Malats, Nuria and Wu, Xifeng and Figueroa, Jonine D. and and Real, Francisco X. and Van den Berg, David and Matullo, Giuseppe and and Baris, Dalsu and Thun, Michael and Kiemeney, Lambertus A. and Vineis, and Paolo and De Vivo, Immaculata and Albanes, Demetrius and Purdue, Mark P. and and Rafnar, Thorunn and Hildebrandt, Michelle A. T. and Kiltie, Anne E. and and Cussenot, Olivier and Golka, Klaus and Kumar, Rajiv and Taylor, Jack and A. and Mayordomo, Jose I. and Jacobs, Kevin B. and Kogevinas, Manolis and and Hutchinson, Amy and Wang, Zhaoming and Fu, Yi-Ping and and Prokunina-Olsson, Ludmila and Burdett, Laurie and Yeager, Meredith and and Wheeler, William and Tardon, Adonina and Serra, Consol and Carrato, and Alfredo and Garcia-Closas, Reina and Lloreta, Josep and Johnson, Alison and and Schwenn, Molly and Karagas, Margaret R. and Schned, Alan and and Andriole, Jr., Gerald and Grubb, III, Robert and Black, Amanda and and Jacobs, Eric J. and Diver, W. Ryan and Gapstur, Susan M. and Weinstein, and Stephanie J. and Virtamo, Jarmo and Cortessis, Victoria K. and and Gago-Dominguez, Manuela and Pike, Malcolm C. and Stern, Mariana C. and and Yuan, Jian-Min and Hunter, David J. and McGrath, Monica and Dinney, and Colin P. and Czerniak, Bogdan and Chen, Meng and Yang, Hushan and and Vermeulen, Sita H. and Aben, Katja K. and Witjes, J. Alfred and and Makkinje, Remco R. and Sulem, Patrick and Besenbacher, Soren and and Stefansson, Kari and Riboli, Elio and Brennan, Paul and Panico, and Salvatore and Navarro, Carmen and Allen, Naomi E. and Bueno-de-Mesquita, and H. Bas and Trichopoulos, Dimitrios and Caporaso, Neil and Landi, Maria and Teresa and Canzian, Federico and Ljungberg, Borje and Tjonneland, Anne and and Clavel-Chapelon, Francoise and Bishop, David T. and Teo, Mark T. W. and and Knowles, Margaret A. and Guarrera, Simonetta and Polidoro, Silvia and and Ricceri, Fulvio and Sacerdote, Carlotta and Allione, Alessandra and and Cancel-Tassin, Geraldine and Selinski, Silvia and Hengstler, Jan G. and and Dietrich, Holger and Fletcher, Tony and Rudnai, Peter and Gurzau, Eugen and and Koppova, Kvetoslava and Bolick, Sophia C. E. and Godfrey, Ashley and and Xu, Zongli and Sanz-Velez, Jose I. and Garcia-Prats, Maria D. and and Sanchez, Manuel and Valdivia, Gabriel and Porru, Stefano and Benhamou, and Simone and Hoover, Robert N. and Fraumeni, Jr., Joseph F. and Silverman, and Debra T. and Chanock, Stephen J.",
    journal = "Nature Genetics",
    year = "2010",
    volume = "42",
    number = "11",
    pages = "978-U98",
    publisher = "Nature Publishing Group",
    issn = "1061-4036, 1546-1718",
    doi = "10.1038/ng.687",
    abstract = "We conducted a multi-stage, genome-wide association study of bladder
cancer with a primary scan of 591,637 SNPs in 3,532 affected individuals
(cases) and 5,120 controls of European descent from five studies
followed by a replication strategy, which included 8,382 cases and
48,275 controls from 16 studies. In a combined analysis, we identified
three new regions associated with bladder cancer on chromosomes 22q13.1,
19q12 and 2q37.1: rs1014971, (P = 8 x 10(-12)) maps to a non-genic
region of chromosome 22q13.1, rs8102137 (P = 2 x 10(-11)) on 19q12 maps
to CCNE1 and rs11892031 (P = 1 x 10(-7)) maps to the UGT1A cluster on
2q37.1. We confirmed four previously identified genome-wide associations
on chromosomes 3q28, 4p16.3, 8q24.21 and 8q24.3, validated previous
candidate associations for the GSTM1 deletion (P = 4 x 10(-11)) and a
tag SNP for NAT2 acetylation status (P = 4 x 10(-11)), and found
interactions with smoking in both regions. Our findings on common
variants associated with bladder cancer risk should provide new insights
into the mechanisms of carcinogenesis."
}