@article{3148991,
    title = "The association between change in body mass index and upper
aerodigestive tract cancers in the ARCAGE project: multicenter
case-control study",
    author = "Park, Sungshim Lani and Lee, Yuan-Chin Amy and Marron, Manuela and and Agudo, Antonio and Ahrens, Wolfgang and Barzan, Luigi and Bencko, and Vladimir and Benhamou, Simone and Bouchardy, Christine and Canova, and Cristina and Castellsague, Xavier and Conway, David I. and Healy, Claire and M. and Holcatova, Ivana and Kjaerheim, Kristina and Lagiou, Pagona and and Lowry, Raymond J. and Macfarlane, Tatiana V. and Macfarlane, Gary J. and and McCartan, Bernard E. and McKinney, Patricia A. and Merletti, Franco and and Pohlabeln, Hermann and Richiardi, Lorenzo and Simonato, Lorenzo and and Sneddon, Linda and Talamini, Renato and Trichopoulos, Dimitrios and and Znaor, Ariana and Brennan, Paul and Hashibe, Mia",
    journal = "International Journal  of Cancer",
    year = "2011",
    volume = "128",
    number = "6",
    pages = "1449-1461",
    publisher = "Wiley",
    issn = "0020-7136",
    doi = "10.1002/ijc.25468",
    keywords = "BMI; BMI change; upper aerodigestive tract cancers",
    abstract = "Previous studies reported an inverse relationship between body mass
index (BMI) and upper aerodigestive tract (UADT) cancers. Examining
change in BMI over time may clarify these previous observations. We used
data from 2,048 cases and 2,173 hospital- and population-based controls
from ten European countries (alcohol-related cancers and genetic
susceptibility in Europe study) to investigate the relationship with BMI
and adult change in BMI on UADT cancer risk. Odds ratios (ORs) and 95%
confidence intervals (CIs) were estimated for associations between BMI
at three time intervals and BMI change on UADT cancer development,
adjusting for center, age, sex, education, fruit and vegetable intake,
smoking and alcohol consumption. We found an inverse relationship
between UADT cancers and BMI at time of interview and 2 years before
interview. No association was found with BMI at 30 years of age.
Regarding BMI change between age 30 and 2 years before interview, BMI
decrease (BMI change <-5%) vs. BMI stability (-5% <= BMI change <5%)
showed no overall association with UADT cancers (OR = 1.15; 95% CI =
0.89, 1.49). An increase in BMI (BMI change >= + 5%) was inversely
associated with UADT cancers (OR = 0.74; 95% CI = 0.62, 0.89). BMI gain
remained inversely associated across all subsites except for esophageal
cancer. When stratified by smoking or by drinking, association with BMI
gain was detected only in drinkers and smokers. In conclusion, BMI gain
is inversely associated with UADT cancers. These findings may be
influenced by smoking and/or drinking behaviors and/or the development
of preclinical UADT cancers and should be corroborated in studies of a
prospective nature."
}