@article{3149019,
    title = "Synchronous well differentiated neuroendocrine tumour and
gastrointestinal stromal tumour of the stomach: a case report",
    author = "Samaras, Vassilis D. and Foukas, Periklis G. and Triantafyllou, and Konstantinos and Leontara, Vassilia and Tsapralis, Dimitrios and and Tsompanidi, Eirini M. and Machairas, Anastasios and Panayiotides, and Ioannis G.",
    journal = "BMC Gastroenterology",
    year = "2011",
    volume = "11",
    publisher = "BMC",
    issn = "1471-230X",
    doi = "10.1186/1471-230X-11-27",
    abstract = "Background: Well differentiated neuroendocrine tumours (carcinoids),
arising from cells of the diffuse neuroendocrine system, represent the
most commonly encountered gastric endocrine tumours. Gastrointestinal
stromal tumours (GISTs), which stem from interstitial Cajal cells
located within the wall of the gastrointestinal tract and have a
characteristic immunoreactivity for CD117 (c-kit protein), account for
the majority of gastrointestinal mesenchymal neoplasms. Simultaneous
occurrence of a GIST with a well differentiated neuroendocrine tumour in
the stomach is very rare.
Methods: Clinical history, endoscopy and histopathological findings were
utilized for our diagnostic considerations.
Results: We report the coexistence of a high risk GIST with a well
differentiated neuroendocrine tumour of benign clinical behavior, both
located in the stomach, in a 62-year-old man previously operated for a
gastric well differentiated neuroendocrine tumour with uncertain
malignant behaviour.
Conclusions: Even single well differentiated, sporadic, NETs of small
size may coexist with GISTs. An appropriate initial therapeutic approach
combined with a scrupulous follow-up seems to play a significant role in
terms of preventing a metastatic disease."
}