@article{3150657, title = "Anthropometric Measures, Physical Activity, and Risk of Glioma and Meningioma in a Large Prospective Cohort Study", author = "Michaud, Dominique S. and Bove, Gerald and Gallo, Valentina and and Schlehofer, Brigitte and Tjonneland, Anne and Olsen, Anja and Overvad, and Kim and Dahm, Christina C. and Teucher, Brigit and Boeing, Heiner and and Steffen, Annika and Trichopoulou, Antonia and Bamia, Christina and and Kyrozis, Andreas and Sacerdote, Carlotta and Agnoli, Claudia and Palli, and Domenico and Tumino, Rosario and Mattiello, Amalia and and Bueno-de-Mesquita, H. Bas and Peeters, Petra H. M. and May, Anne M. and and Barricarte, Aurelio and Chirlaque, Maria-Dolores and Dorronsoro, Miren and and Jose Sanchez, Maria and Rodriguez, Laudina and Duell, Eric J. and and Hallmans, Goran and Melin, Beatrice S. and Manjer, Jonas and Borgquist, and Signe and Khaw, Kay-Tee and Wareham, Nick and Allen, Naomi E. and and Travis, Ruth C. and Romieu, Isabelle and Vineis, Paolo and Riboli, Elio", journal = "Cancer Prevention Research", year = "2011", volume = "4", number = "9", pages = "1385-1392", publisher = "AMER ASSOC CANCER RESEARCH", issn = "1940-6207, 1940-6215", doi = "10.1158/1940-6207.CAPR-11-0014", abstract = "Body fatness has been associated with increased risk of a number of hormone-dependent cancers. Recent studies suggest that body mass index (BMI) may be related to meningiomas, which are more common in women than men, and for which estrogens are believed to play a role. Using data from a large European propective cohort, 203 incident cases of meningioma and 340 cases of glioma were included in the analysis for measures of body fat, height, and physical activity among 380,775 participants. All analyses were conducted using Cox proportional hazards model and controlling for age, sex, country, and education. A 71% increase in risk of meningioma was observed among men and women in the top quartile of waist circumference (HR = 1.71, 95% CI = 1.08-2.73, P-trend = 0.01). A positive association was also observed for BMI and meningioma (HR = 1.48, 95% CI = 0.98-2.23, for BMI >= 30 compared with a BMI of 20-24.9, P-trend = 0.05). An association with height and meningioma was also suggestive (HR = 1.24, 95% 0.96-1.51, for each 10 cm increase). In contrast, no associations were observed for height and different measures of body fat and risk of glioma. Physical activity was not related to either type of brain tumors. Results from this study support an increase in risk of meningioma with higher body fatness among both men and women. No association was observed between anthropometric measures and risk of glioma. Cancer Prev Res; 4(9); 1385-92. (C) 2011 AACR." }