@article{3151620,
    title = "New gene functions in megakaryopoiesis and platelet formation",
    author = "Gieger, Christian and Radhakrishnan, Aparna and Cvejic, Ana and Tang, and Weihong and Porcu, Eleonora and Pistis, Giorgio and Serbanovic-Canic, and Jovana and Elling, Ulrich and Goodall, Alison H. and Labrune, Yann and and Lopez, Lorna M. and Maegi, Reedik and Meacham, Stuart and Okada, and Yukinori and Pirastu, Nicola and Sorice, Rossella and Teumer, Alexander and and Voss, Katrin and Zhang, Weihua and Ramirez-Solis, Ramiro and Bis, and Joshua C. and Ellinghaus, David and Goegele, Martin and Hottenga, and Jouke-Jan and Langenberg, Claudia and Kovacs, Peter and O'Reilly, Paul and F. and Shin, So-Youn and Esko, Toenu and Hartiala, Jaana and Kanoni, and Stavroula and Murgia, Federico and Parsa, Afshin and Stephens, Jonathan and and van der Harst, Pim and van der Schoot, C. Ellen and Allayee, Hooman and and Attwood, Antony and Balkau, Beverley and Bastardot, Francois and and Basu, Saonli and Baumeister, Sebastian E. and Biino, Ginevra and Bomba, and Lorenzo and Bonnefond, Amelie and Cambien, Francois and Chambers, John and C. and Cucca, Francesco and D'Adamo, Pio and Davies, Gail and de Boer, and Rudolf A. and de Geus, Eco J. C. and Doering, Angela and Elliott, Paul and and Erdmann, Jeanette and Evans, David M. and Falchi, Mario and Feng, and Wei and Folsom, Aaron R. and Frazer, Ian H. and Gibson, Quince D. and and Glazer, Nicole L. and Hammond, Chris and Hartikainen, Anna-Liisa and and Heckbert, Susan R. and Hengstenberg, Christian and Hersch, Micha and and Illig, Thomas and Loos, Ruth J. F. and Jolley, Jennifer and Khaw, Kay and Tee and Kuehnel, Brigitte and Kyrtsonis, Marie-Christine and Lagou, and Vasiliki and Lloyd-Jones, Heather and Lumley, Thomas and Mangino, and Massimo and Maschio, Andrea and Leach, Irene Mateo and McKnight, Barbara and and Memari, Yasin and Mitchell, Braxton D. and Montgomery, Grant W. and and Nakamura, Yusuke and Nauck, Matthias and Navis, Gerjan and Noethlings, and Ute and Nolte, Ilja M. and Porteous, David J. and Pouta, Anneli and and Pramstaller, Peter P. and Pullat, Janne and Ring, Susan M. and Rotter, and Jerome I. and Ruggiero, Daniela and Ruokonen, Aimo and Sala, Cinzia and and Samani, Nilesh J. and Sambrook, Jennifer and Schlessinger, David and and Schreiber, Stefan and Schunkert, Heribert and Scott, James and Smith, and Nicholas L. and Snieder, Harold and Starr, John M. and Stumvoll, Michael and and Takahashi, Atsushi and Tang, W. H. Wilson and Taylor, Kent and and Tenesa, Albert and Thein, Swee Lay and Toenjes, Anke and Uda, Manuela and and Ulivi, Sheila and van Veldhuisen, Dirk J. and Visscher, Peter M. and and Voelker, Uwe and Wichmann, H-Erich and Wiggins, Kerri L. and Willemsen, and Gonneke and Yang, Tsun-Po and Zhao, Jing Hua and Zitting, Paavo and and Bradley, John R. and Dedoussis, George V. and Gasparini, Paolo and and Hazen, Stanley L. and Metspalu, Andres and Pirastu, Mario and Shuldiner, and Alan R. and van Pelt, L. Joost and Zwaginga, Jaap-Jan and Boomsma, and Dorret I. and Deary, Ian J. and Franke, Andre and Froguel, Philippe and and Ganesh, Santhi K. and Jarvelin, Marjo-Riitta and Martin, Nicholas G. and and Meisinger, Christa and Psaty, Bruce M. and Spector, Timothy D. and and Wareham, Nicholas J. and Akkerman, Jan-Willem N. and Ciullo, Marina and and Deloukas, Panos and Greinacher, Andreas and Jupe, Steve and Kamatani, and Naoyuki and Khadake, Jyoti and Kooner, Jaspal S. and Penninger, Josef and and Prokopenko, Inga and Stemple, Derek and Toniolo, Daniela and and Wernisch, Lorenz and Sanna, Serena and Hicks, Andrew A. and Rendon, and Augusto and Ferreira, Manuel A. and Ouwehand, Willem H. and Soranzo, and Nicole",
    journal = "Nature Metabolism",
    year = "2011",
    volume = "480",
    number = "7376",
    pages = "201-208",
    publisher = "Nature Publishing Group",
    doi = "10.1038/nature10659",
    abstract = "Platelets are the second most abundant cell type in blood and are
essential for maintaining haemostasis. Their count and volume are
tightly controlled within narrow physiological ranges, but there is only
limited understanding of the molecular processes controlling both
traits. Here we carried out a high-powered meta-analysis of genome-wide
association studies (GWAS) in up to 66,867 individuals of European
ancestry, followed by extensive biological and functional assessment. We
identified 68 genomic loci reliably associated with platelet count and
volume mapping to established and putative novel regulators of
megakaryopoiesis and platelet formation. These genes show
megakaryocyte-specific gene expression patterns and extensive network
connectivity. Using gene silencing in Danio rerio and Drosophila
melanogaster, we identified 11 of the genes as novel regulators of blood
cell formation. Taken together, our findings advance understanding of
novel gene functions controlling fate-determining events during
megakaryopoiesis and platelet formation, providing a new example of
successful translation of GWAS to function."
}