@article{3152157,
    title = "TGF-beta signalling in colon carcinogenesis",
    author = "Lampropoulos, Pavlos and Zizi-Sermpetzoglou, Adamantia and Rizos, Spyros and and Kostakis, Alkiviadis and Nikiteas, Nikolaos and Papavassiliou, and Athanasios G.",
    journal = "Cancer Letter",
    year = "2012",
    volume = "314",
    number = "1",
    pages = "1-7",
    publisher = "Elsevier Ireland Ltd",
    doi = "10.1016/j.canlet.2011.09.041",
    keywords = "TGF-beta signalling pathway; Colorectal cancer (CRC); Targeted therapy",
    abstract = "Colorectal cancer remains the most common cancer and the second leading
cause of cancer mortality in Europe. There are a number of pathways that
have been implicated in colorectal carcinogenesis, including TGF-beta
(TGF-beta)/Smad signalling pathway. The TGF-beta pathway is involved in
several biological processes, including cell proliferation,
differentiation, migration and apoptosis. Here we review the role of
TGF-beta signalling cascade in colorectal carcinogenesis and provide
some new molecular insights that may aid efforts towards targeted
antitumor therapies. (C) 2011 Elsevier Ireland Ltd. All rights reserved."
}