@article{3153125,
    title = "Biomarkers of Oxidative Stress and Risk of Developing Colorectal Cancer:
A Cohort-nested Case-Control Study in the European Prospective
Investigation Into Cancer and Nutrition",
    author = "Leufkens, Anke M. and van Duijnhoven, Franzel J. B. and Woudt, Sjoukje and H. S. and Siersema, Peter D. and Jenab, Mazda and Jansen, Eugene H. J. and M. and Pischon, Tobias and Tjonneland, Anne and Olsen, Anja and Overvad, and Kim and Boutron-Ruault, Marie Christine and Clavel-Chapelon, Francoise and and Morois, Sophie and Palli, Domenico and Pala, Valeria and Tumino, and Rosario and Vineis, Paolo and Panico, Salvatore and Kaaks, Rudolf and and Lukanova, Annekatrin and Boeing, Heiner and Aleksandrova, Krasimira and and Trichopoulou, Antonia and Trichopouios, Dimitrios and Dilis, Vardis and and Peeters, Petra H. and Skeie, Guri and Gonzalez, Carlos A. and and Argueelles, Marcial and Sanchez, Maria-Jose and Dorronsoro, Miren and and Huerta, Jose Maria and Ardanaz, Eva and Hallmans, Goran and Palmqvist, and Richard and Khaw, Kay-Tee and Wareham, Nick and Allen, Naomi E. and and Crowe, Francesca L. and Fedirko, Veronika and Norat, Teresa and Riboli, and Elio and Bueno-de-Mesquita, H. Bas",
    journal = "American Journal of Epidemiology",
    year = "2012",
    volume = "175",
    number = "7",
    pages = "653-663",
    publisher = "OXFORD UNIV PRESS INC",
    issn = "0002-9262, 1476-6256",
    doi = "10.1093/aje/kwr418",
    keywords = "biological markers; case-control studies; colorectal neoplasms;
oxidative stress",
    abstract = "Oxidative stress has been shown to play an important role in
carcinogenesis, but prospective evidence for an association between
biomarkers of oxidative stress and colorectal cancer (CRC) risk is
limited. The authors investigated the association between prediagnostic
serum levels of oxidative stress indicators (i.e., reactive oxygen
metabolites (ROM) and ferric reducing ability of plasma (FRAP)) and CRC
risk. This was examined in a nested case-control study (1,064 CRC cases,
1,064 matched controls) in the European Prospective Investigation Into
Cancer and Nutrition cohort (1992-2003). Incidence rate ratios and 95%
confidence intervals were calculated using conditional logistic
regression analyses. ROM were associated with overall CRC risk (highest
tertile vs. lowest: adjusted incidence rate ratio (IRRadj) = 1.91, 95%
confidence interval (CI): 1.47, 2.48), proximal (IRRadj = 1.89, 95% CI:
1.06, 3.36) and distal (IRRadj = 2.31, 95% CI: 1.37, 3.89) colon
cancer, and rectal cancer (IRRadj = 1.69, 95% CI: 1.05, 2.72). When
results were stratified by tertile of follow-up time, the association
remained significant only in participants with less than 2.63 years of
follow-up (IRRadj = 2.28, 95% CI: 1.78, 2.94; P-heterogeneity < 0.01).
FRAP was not associated with CRC risk. In conclusion, prediagnostic
serum ROM levels were associated with increased risk of CRC. However,
this association was seen only in subjects with relatively short
follow-up, suggesting that the association results from production of
reactive oxygen species by preclinical tumors."
}