@article{3153183,
    title = "Ovarian Cancer and Body Size: Individual Participant Meta-Analysis
Including 25,157 Women with Ovarian Cancer from 47 Epidemiological
Studies",
    author = "Beral, V. and Hermon, C. and Peto, R. and Reeves, G. and Brinton, L. and and Marchbanks, P. and Negri, E. and Ness, R. and Peeters, P. H. M. and and Vessey, M. and Calle, E. E. and Gapstur, S. M. and Patel, A. V. and Dal and Maso, L. and Talamini, R. and Chetrit, A. and Hirsh-Yechezkel, G. and and Lubin, F. and Sadetzki, S. and Allen, N. and Bull, D. and Callaghan, K. and and Crossley, B. and Gaitskell, K. and Goodill, A. and Green, J. and and Key, T. and Moser, K. and Collins, R. and Doll, R. and Gonzalez, C. A. and and Lee, N. and Ory, H. W. and Peterson, H. B. and Wingo, P. A. and and Martin, N. and Pardthaisong, T. and Silpisornkosol, S. and Theetranont, and C. and Boosiri, B. and Chutivongse, S. and Jimakorn, P. and Virutamasen, and P. and Wongsrichanalai, C. and Tjonneland, A. and Titus-Ernstoff, L. and and Byers, T. and Rohan, T. and Mosgaard, B. J. and Yeates, D. and and Freudenheim, J. L. and Chang-Claude, J. and Kaaks, R. and Anderson, K. and E. and Folsom, A. and Robien, K. and Rossing, M. A. and Thomas, D. B. and and Weiss, N. S. and Riboli, E. and Clavel-Chapelon, F. and Cramer, D. and and Hankinson, S. E. and Tworoger, S. S. and Franceschi, S. and La and Vecchia, C. and Magnusson, C. and Riman, T. and Weiderpass, E. and Wolk, and A. and Schouten, L. J. and van den Brandt, P. A. and Chantarakul, N. and and Koetsawang, S. and Rachawat, D. and Palli, D. and Black, A. and de and Gonzalez, A. Berrington and Freedman, D. M. and Hartge, P. and Hsing, A. and W. and Lacey, Jr., J. V. and Hoover, R. N. and Schairer, C. and and Graff-Iversen, S. and Selmer, R. and Bain, C. J. and Green, A. C. and and Purdie, D. M. and Siskind, V. and Webb, P. M. and McCann, S. E. and and Hannaford, P. and Kay, C. and Binns, C. W. and Lee, A. H. and Zhang, M. and and Ness, R. B. and Nasca, P. and Coogan, P. F. and Palmer, J. R. and and Rosenberg, L. and Kelsey, J. and Paffenbarger, R. and Whittemore, A. and and Katsouyanni, K. and Trichopoulou, A. and Trichopoulos, D. and Tzonou, A. and and Dabancens, A. and Martinez, L. and Molina, R. and Salas, O. and and Goodman, M. T. and Lurie, G. and Carney, M. E. and Wilkens, L. R. and and Hartman, L. and Manjer, J. and Olsson, H. and Grisso, J. A. and Morgan, and M. and Wheeler, J. E. and Casagrande, J. and Pike, M. C. and Ross, R. K. and and Wu, A. H. and Miller, A. B. and Kumle, M. and Lund, E. and McGowan, and L. and Shu, X. O. and Zheng, W. and Farley, T. M. M. and Holck, S. and and Meirik, O. and Risch, H. A. and Collaborative Grp Epidemiol Studie",
    journal = "PLoS Medicine",
    year = "2012",
    volume = "9",
    number = "4",
    publisher = "Public Library of Science",
    issn = "1549-1277, 1549-1676",
    doi = "10.1371/journal.pmed.1001200",
    abstract = "Background: Only about half the studies that have collected information
on the relevance of women’s height and body mass index to their risk of
developing ovarian cancer have published their results, and findings are
inconsistent. Here, we bring together the worldwide evidence, published
and unpublished, and describe these relationships.
Methods and Findings: Individual data on 25,157 women with ovarian
cancer and 81,311 women without ovarian cancer from 47 epidemiological
studies were collected, checked, and analysed centrally. Adjusted
relative risks of ovarian cancer were calculated, by height and by body
mass index. Ovarian cancer risk increased significantly with height and
with body mass index, except in studies using hospital controls. For
other study designs, the relative risk of ovarian cancer per 5 cm
increase in height was 1.07 (95% confidence interval [CI], 1.05-1.09;
p<0.001); this relationship did not vary significantly by women’s age,
year of birth, education, age at menarche, parity, menopausal status,
smoking, alcohol consumption, having had a hysterectomy, having first
degree relatives with ovarian or breast cancer, use of oral
contraceptives, or use of menopausal hormone therapy. For body mass
index, there was significant heterogeneity (p<0.001) in the findings
between ever-users and never-users of menopausal hormone therapy, but
not by the 11 other factors listed above. The relative risk for ovarian
cancer per 5 kg/m(2) increase in body mass index was 1.10 (95% CI,
1.07-1.13; p<0.001) in never-users and 0.95 (95% CI, 0.92-0.99; p =
0.02) in ever-users of hormone therapy.
Conclusions: Ovarian cancer is associated with height and, among
never-users of hormone therapy, with body mass index. In high-income
countries, both height and body mass index have been increasing in birth
cohorts now developing the disease. If all other relevant factors had
remained constant, then these increases in height and weight would be
associated with a 3% increase in ovarian cancer incidence per decade."
}