@article{3153317, title = "Myocardial Structure and Matrix Metalloproteinases", author = "Aggeli, C. and Pietri, P. and Felekos, I. and Rautopoulos, L. and and Toutouzas, K. and Tsiamis, E. and Stefanadis, C.", journal = "Current Topics in Medicinal Chemistry", year = "2012", volume = "12", number = "10", pages = "1113-1131", publisher = "BENTHAM SCIENCE PUBL LTD", issn = "1568-0266", doi = "10.2174/1568026611208011113", keywords = "Metaloproteinases; myocardial structure", abstract = "Metalloproteinases (MMPs) are enzymes which enhance proteolysis of extracellular matrix proteins. The pathophysiologic and prognostic role of MMPs has been demonstrated in numerous studies. The present review covers a wide a range of topics with regards to MMPs structural and functional properties, as well as their role in myocardial remodeling in several cardiovascular diseases. Moreover, the clinical and therapeutic implications from their assessment are highlighted." }