@article{3154113,
    title = "Leptin and Soluble Leptin Receptor in Risk of Colorectal Cancer in the
European Prospective Investigation into Cancer and Nutrition Cohort",
    author = "Aleksandrova, Krasimira and Boeing, Heiner and Jenab, Mazda and and Bueno-de-Mesquita, H. Bas and Jansen, Eugene and van Duijnhoven, Franzel and J. B. and Rinaldi, Sabina and Fedirko, Veronika and Romieu, Isabelle and and Riboli, Elio and Gunter, Marc J. and Westphal, Sabine and Overvad, Kim and and Tjonneland, Anne and Halkjaer, Jytte and Racine, Antoine and and Boutron-Ruault, Marie-Christine and Clavel-Chapelon, Francoise and and Kaaks, Rudolf and Lukanova, Annekatrin and Trichopoulou, Antonia and and Lagiou, Pagona and Trichopoulos, Dimitrios and Mattiello, Amalia and and Pala, Valeria and Palli, Domenico and Tumino, Rosario and Vineis, Paolo and and Buckland, Genevieve and Sanchez, Maria-Jose and Amiano, Pilar and and Maria Huerta, Jose and Barricarte, Aurelio and Menendez, Virginia and and Peeters, Petra H. and Soderberg, Stefan and Palmqvist, Richard and and Allen, Naomi E. and Crowe, Francesca L. and Khaw, Kay-Tee and Wareham, and Nickolas and Pischon, Tobias",
    journal = "Current Cancer Research",
    year = "2012",
    volume = "72",
    number = "20",
    pages = "5328-5337",
    publisher = "AMER ASSOC CANCER RESEARCH",
    doi = "10.1158/0008-5472.CAN-12-0465",
    abstract = "Leptin, a peptide hormone produced primarily by the adipocytes, is
hypothesized to play a role in the pathogenesis of colorectal cancer
(CRC). Soluble leptin receptor (sOB-R) may regulate leptin’s physiologic
functions; however its relation to CRC risk is unknown. This study
explored the association of leptin and sOB-R with risk of CRC in a
prospective nested case-control study within the European Prospective
Investigation into Cancer and Nutrition (EPIC) cohort. A total of 1,129
incident CRC cases (713 colon, 416 rectal) were matched within risk sets
to 1,129 controls. Conditional logistic regression was used to calculate
relative risks (RR) and 95% confidence intervals (CI). After
multivariable adjustment including body mass index (BMI), waist
circumference, and baseline leptin concentrations, sOB-R was strongly
inversely associated with CRC (RR comparing the highest quintile vs. the
lowest, 0.55; 95% CI, 0.40-0.76; P-trend = 0.0004) and colon cancer
(RR, 0.42; 95% CI, 0.28-0.63, P-trend = 0.0001); whereas no association
was seen for rectal cancer (RR adjusted for BMI and waist circumference,
0.83; 95% CI, 0.48-1.44, P-trend = 0.38). In contrast, leptin was not
associated with risk of CRC (RR adjusted for BMI and waist
circumference, 0.85; 95% CI, 0.56-1.29, P-trend = 0.23). Additional
adjustments for circulating metabolic biomarkers did not attenuate these
results. These novel findings suggest a strong inverse association
between circulating sOB-R and CRC risk, independent of obesity measures,
leptin concentrations, and other metabolic biomarkers. Further research
is needed to confirm the potentially important role of sOB-R in CRC
pathogenesis. Cancer Res; 72(20); 5328-37. (C) 2012 AACR."
}