@article{3154343,
    title = "Total and high-molecular weight adiponectin and risk of colorectal
cancer: the European Prospective Investigation into Cancer and Nutrition
Study",
    author = "Aleksandrova, Krasimira and Boeing, Heiner and Jenab, Mazda and and Bueno-de-Mesquita, H. Bas and Jansen, Eugene and van Duijnhoven, Franzel and J. B. and Fedirko, Veronika and Rinaldi, Sabina and Romieu, Isabelle and and Riboli, Elio and Romaguera, Dora and Westphal, Sabine and Overvad, Kim and and Tjonneland, Anne and Boutron-Ruault, Marie Christine and and Clavel-Chapelon, Francoise and Kaaks, Rudolf and Lukanova, Annekatrin and and Trichopoulou, Antonia and Lagiou, Pagona and Trichopoulos, Dimitrios and and Agnoli, Claudia and Mattiello, Amalia and Saieva, Calogero and and Vineis, Paolo and Tumino, Rosario and Peeters, Petra H. and Argueelles, and Marcial and Bonet, Catalina and Sanchez, Maria-Jose and Dorronsoro, and Miren and Huerta, Jose-Maria and Barricarte, Aurelio and Palmqvist, and Richard and Hallmans, Goran and Khaw, Kay-Tee and Wareham, Nick and and Allen, Naomi E. and Crowe, Francesca L. and Pischon, Tobias",
    journal = "Journal of Carcinogenesis",
    year = "2012",
    volume = "33",
    number = "6",
    pages = "1211-1218",
    publisher = "Oxford University Press",
    issn = "1477-3163",
    doi = "10.1093/carcin/bgs133",
    abstract = "Adiponectin an adipose tissue-derived protein may provide a molecular
link between obesity and colorectal cancer (CRC), but evidence from
large prospective studies is limited. In particular, no epidemiological
study explored high-molecular weight (HMW) and non-HMW adiponectin
fractions in relation to CRC risk, despite them being hypothesized to
have differential biological activities, i.e. regulating insulin
sensitivity (HMW adiponectin) versus inflammatory response (non-HNW
adiponectin). In a prospective, nested case control study, we
investigated whether prediagnostic serum concentrations of total, HMW
and non-HMW adiponectin are associated with risk of CRC, independent of
obesity and other known CRC risk factors. A total of 1206 incident cases
(755 colon and 451 rectal) were matched to 1206 controls using
incidence-density sampling. In conditional logistic regression, adjusted
for dietary and lifestyle factors, total adiponectin and non-HMW
adiponectin concentrations were inversely associated with risk of CRC
[relative risk (RR) comparing highest versus lowest quintile = 0.71,
95% confidence interval (CI) = 0.53-0.95, P-trend = 0.03 for total
adiponectin and RR = 0.45, 95% Cl = 0.34-0.61, P-trend < 0.0001 for
non-HMW adiponectin] HMW adiponectin concentrations were not associated
with CRC risk (RR = 0.91, 95% Cl = 0.68-1.22, P-trend = 0.55). Non-HMW
adiponectin was associated with CRC risk even after adjustment for body
mass index and waist circumference (RR = 0.39, 95% CI = 0.26-0.60,
P-trend < 0.0001), whereas the association with total adiponectin was no
longer significant (RR = 0.81, 95% CI = 0.60A.09, P-trend = 0.23). When
stratified by cancer site, non-HMW adiponectin was inversely associated
with both colon and rectal cancer. These findings suggest an important
role of the relative proportion of non-HMW adiponectin in CRC
pathogenesis. Future studies are warranted to confirm these results and
to elucidate the underlying mechanisms."
}