@article{3156587,
    title = "Clinical Outcome and Safety of Multilevel Vertebroplasty: Clinical
Experience and Results",
    author = "Mailli, Leto and Filippiadis, Dimitrios K. and Brountzos, Elias N. and and Alexopoulou, Efthymia and Kelekis, Nikolaos and Kelekis, Alexios",
    journal = "CardioVascular and Interventional Radiology",
    year = "2013",
    volume = "36",
    number = "1",
    pages = "183-191",
    publisher = "Springer-Verlag",
    issn = "0174-1551, 1432-086X",
    doi = "10.1007/s00270-012-0379-z",
    keywords = "Vertebroplasty; Multilevel; Metastasis; Osteoporosis; Multiple myeloma",
    abstract = "To compare safety and efficacy of percutaneous vertebroplasty (PVP) when
treating up to three vertebrae or more than three vertebrae per session.
We prospectively compared two groups of patients with symptomatic
vertebral fractures who had no significant response to conservative
therapy. Pathologic substrate included osteoporosis (n = 77), metastasis
(n = 24), multiple myeloma (n = 13), hemangioma (n = 15), and lymphoma
(n = 1). Group A patients (n = 94) underwent PVP of up to three treated
vertebrae (n = 188). Group B patients (n = 36) underwent PVP with more
than three treated vertebrae per session (n = 220). Decreased pain and
improved mobility were recorded the day after surgery and at 12 and 24
months after surgery per clinical evaluation and the use of numeric
visual scales (NVS): the Greek Brief Pain Inventory, a linear analogue
self-assessment questionnaire, and a World Health Organization
questionnaire.
Group A presented with a mean pain score of 7.9 +/- A 1.1 NVS units
before PVP, which decreased to 2.1 +/- A 1.6, 2.0 +/- A 1.5 and 2.0 +/-
A 1.5 NVS units the day after surgery and at 12 and 24 months after
surgery, respectively. Group B presented with a mean pain score of 8.1
+/- A 1.3 NVS units before PVP, which decreased to 2.2 +/- A 1.3, 2.0
+/- A 1.5, and 2.1 +/- A 1.6 NVS units the day after surgery and at 12
and 24 months after surgery, respectively. Overall pain decrease and
mobility improvement throughout the follow-up period presented no
statistical significance neither between the two groups nor between
different underlying aetiology. Reported cement leakages presented no
statistical significance between the two groups (p = 0.365).
PVP is an efficient and safe technique for symptomatic vertebral
fractures independently of the vertebrae number treated per session."
}