@article{3156621,
    title = "Alcohol drinking and endometrial cancer risk in the European Prospective
Investigation into Cancer and Nutrition (EPIC) study",
    author = "Fedirko, Veronika and Jenab, Mazda and Rinaldi, Sabina and Biessy, and Carine and Allen, Naomi E. and Dossus, Laure and Onland-Moret, N. and Charlotte and Schuetze, Madlen and Tjonneland, Anne and Hansen, Louise and and Overvad, Kim and Clavel-Chapelon, Francoise and Chabbert-Buffet, and Nathalie and Kaaks, Rudolf and Lukanova, Annekatrin and Bergmann, and Manuela M. and Boeing, Heiner and Trichopoulou, Antonia and Oustoglou, and Erifili and Barbitsioti, Antonia and Saieva, Calogero and Tagliabue, and Giovanna and Galasso, Rocco and Tumino, Rosario and Sacerdote, Carlotta and and Peeters, Petra H. and Bueno-de-Mesquita, H. Bas and Weiderpass, and Elisabete and Gram, Inger Torhild and Sanchez, Soledad and Duell, Eric and J. and Molina-Montes, Esther and Arriola, Larraitz and Chirlaque, and Maria-Dolores and Ardanaz, Eva and Manjer, Jonas and Lundin, Eva and and Idahl, Annika and Khaw, Kay-Tee and Romaguera-Bosch, Dora and Wark, and Petra A. and Norat, Teresa and Romieu, Isabelle",
    journal = "ANNALS OF EPIDEMIOLOGY",
    year = "2013",
    volume = "23",
    number = "2",
    pages = "93-98",
    publisher = "EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC",
    issn = "1047-2797",
    doi = "10.1016/j.annepidem.2012.11.009",
    keywords = "Endometrial neoplasms; Ethanol; Cohort studies; Western Europe",
    abstract = "Purpose: Alcohol intake may adversely affect the concentrations of
endogenous sex hormones, and thus increase the risk of endometrial
cancer. However, epidemiologic studies have provided conflicting
results. Therefore, we investigated the association between alcohol
intake and endometrial cancer risk a large, multicenter, prospective
study.
Methods: From 1992 through 2010, 301,051 women in the European
Prospective Investigation into Cancer and Nutrition (EPIC) cohort were
followed for incident endometrial cancer (n = 1382). Baseline alcohol
consumption was assessed by country-specific, validated dietary
questionnaires. Information on past alcohol consumption was collected by
lifestyle questionnaires. Hazard ratios (HRs) and 95% confidence
intervals (CIs) were estimated from Cox proportional hazard models.
Results: The multivariable HRs (and 95% CIs) compared with light
drinkers (0.1-6 g/d) were 1.03(0.88-1.20) for 0 g of alcohol per day at
baseline, 1.01 (0.86-1.17) for 6.1-12 g/d, 1.03 (0.87-1.22) for 12.1-24
g/d, 1.07(0.87-1.38) for 241-36 g/d, and 0.85(0.61-1.18) for more than
36 g/d (p(trend) = 0.77). No association was observed among former
drinkers (OR, 1.28; 95% CI, 0.98-1.68 compared with light drinkers).
Null associations were also found between alcohol consumption at age 20
years, lifetime pattern of alcohol drinking, and baseline alcohol intake
from specific alcoholic beverages and endometrial cancer risk.
Conclusions: Our findings suggest no association between alcohol intake
and endometrial cancer risk. (c) 2013 Elsevier Inc. All rights reserved."
}