@article{3157974,
    title = "Impaired glucose homeostasis in non-diabetic Greek hypertensives with
diabetes family history. Effect of the obesity status",
    author = "Vyssoulis, Gregory P. and Liakos, Charalampos I. and Karpanou, Eva A. and and Triantafyllou, Athanasios I. and Michaelides, Andreas P. and Tzamou, and Vanessa E. and Markou, Maria I. and Stefanadis, Christodoulos I.",
    journal = "Journal of the American Society of Hypertension",
    year = "2013",
    volume = "7",
    number = "4",
    pages = "294-304",
    publisher = "EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC",
    issn = "1933-1711",
    doi = "10.1016/j.jash.2013.02.007",
    keywords = "Arterial hypertension; diabetes family history; impaired glucose
homeostasis; obesity; pre-diabetes; type 2 diabetes",
    abstract = "Arterial hypertension (AH) and diabetes mellitus (DM) are established
cardiovascular risk factors. Impaired glucose homeostasis (IGH; impaired
fasting glucose or/and impaired glucose tolerance) or pre-diabetes,
obesity, and DM family history identify individuals at risk for type 2
DM in whom preventive interventions are necessary. The aim of this study
was to determine the glycemic profile in non-diabetic Greek adult
hypertensive men and women according to DM family history and the
obesity status. Diabetes family history, obesity markers (waist-to-hip
ratio, WHR; body mass index, BMI), glycemic parameters (fasting and
2-hour post-load plasma glucose, if necessary; glycated hemoglobin,
HbA(l)c; fasting insulin), insulin resistance indices (homeostasis model
assessment, HOMA; quantitative insulin sensitivity check index, QUICKI;
Bennett; McAuley), and IGH prevalence were determined in a large cohort
of 11,540 Greek hypertensives referred to our institutions. Positive DM
family history was associated with elevated fasting glucose (98.6 +/-
13.1 vs 96.5 +/- 12.3 mg/dL), HbA(l)c (5.58% +/- 0.49% vs 5.50% +/-
0.46%), fasting insulin (9.74 +/- 4.20 vs 9.21 +/- 3.63 mu U/mL) and
HOMA (2.43 +/- 1.19 vs 2.24 +/- 1.01) values, lower QUICKI (0.342 +/-
0.025 vs 0.345 +/- 0.023), Bennett (0.285 +/- 0.081 vs 0.292 +/- 0.078)
and McAuley (6.73 +/- 3.43 vs 6.95 +/- 3.44) values, and higher IGH
prevalence (45.3% vs 38.7%); P < .01 for all comparisons. The
difference in the prevalence of IGH according to DM family history was
significant (P < .01) in both genders and every WHR and BMI subgroup
(except for women with BMI <20 kg/m(2)). Non-diabetic hypertensives with
positive DM family history present with higher IGH prevalence and worse
glycemic indices levels compared with those with negative family
history, especially in the higher WHR/BMI subgroups. (c) 2013 American
Society of Hypertension. All rights reserved."
}