@article{3159058,
    title = "Determinants of quality of life of patients with heart failure and iron
deficiency treated with ferric carboxymaltose: FAIR-HF sub-analysis",
    author = "Gutzwiller, Florian S. and Pfeil, Alena M. and Comin-Colet, Josep and and Ponikowski, Piotr and Filippatos, Gerasimos and Mori, Claudio and and Braunhofer, Peter G. and Szucs, Thomas D. and Schwenkglenks, Matthias and and Anker, Stefan D.",
    journal = "International Journal of Cardiology",
    year = "2013",
    volume = "168",
    number = "4",
    pages = "3878-3883",
    publisher = "Elsevier Ireland Ltd",
    issn = "0167-5273",
    doi = "10.1016/j.ijcard.2013.06.045",
    keywords = "Quality of life; Heart failure; Anaemia; Iron deficiency; Ferric
carboxymaltose; Multivariate analysis",
    abstract = "Background: Heart failure (HF) is a burden to patients and health care
systems. The objectives of HF treatment are to improve health related
quality of life (HRQoL) and reduce mortality and morbidity. We aimed to
evaluate determinants of health-related quality of life (HRQoL) in
patients with iron deficiency and HF treated with intravenous (i.v.)
iron substitution or placebo.
Methods: A randomised, double-blind, placebo-controlled trial (n = 459)
in iron-deficient chronic heart failure (CHF) patients with or without
anaemia studied clinical and HRQoL benefits of i.v. iron substitution
using ferric carboxymaltose (FCM) over a 24-week trial period.
Multivariate analysis was carried out with various clinical variables as
independent variables and HRQoL measures as dependent variables.
Results: Mean change from baseline of European Quality of Life - 5
Dimensions (EQ-5D) (value set-based) utilities (on a 0 to 100 scale) at
week 24 was 8.91 (i.v. iron) and 0.68 (placebo; p < 0.01). In a
multivariate analysis excluding baseline HRQoL, a higher exercise
tolerance and i.v. iron substitution positively influenced HRQoL,
whereas impaired renal function and a history of stroke had a negative
effect. The level of HRQoL was also influenced by country of residence.
When baseline HRQoL was factored in, the multivariate model remained
stable.
Conclusion: In this study, i.v. iron substitution, exercise tolerance,
stroke, country of residence and renal function influenced measures of
HRQoL in patients with heart failure and iron deficiency. (C) 2013 The
Authors. Published by Elsevier Ireland Ltd. All rights reserved."
}