@article{3159300,
    title = "Prevalence of non classical congenital adrenal hyperplasia due to
21-hydroxylase deficiency in Greek women with acne: a hospital-based
cross-sectional study",
    author = "Trakakis, E. and Papadavid, E. and Dalamaga, M. and Koumaki, D. and and Stavrianeas, N. and Rigopoulos, D. and Creatsas, G. and Kassanos, D.",
    journal = "Journal of the European Academy of Dermatology and Venereology",
    year = "2013",
    volume = "27",
    number = "11",
    pages = "1448-1451",
    publisher = "Wiley-Blackwell",
    issn = "0926-9959, 1468-3083",
    doi = "10.1111/j.1468-3083.2012.04613.x",
    abstract = "Aim To determine the prevalence and frequency of non classical
congenital adrenal hyperplasia (NC-CAH) due to 21-OHD at the time of
clinical presentation and at the peripubertal period in a substantial
sample of Greek women with acne and to investigate the correlation of
serum T, 17-OHP and DHEA-S with acne appearance at the time of clinical
presentation. Methods One hundred and twenty-three unselected women with
hyperandrogenemic symptoms were examined. After the ACTH stimulation
test, 6 (4.9%) women were diagnosed with NC-CAH due to 21-OHD. Results
There was not any statistical significant difference in the frequency of
peripubertal acne between NC-CAH group of patients (6.4%) and patients
with hyperandrogenemia of other aetiology (93%), mainly ovarian
(P=0.41). However, there was a statistical significant difference in the
prevalence of acne at the time of clinical examination between the two
groups (P=0.04). Acne was present in 83.3% of women with NC-CAH vs.
41.02% of women in the hyperandrogenic group without NC-CAH. A
statistically significant decrease of acne from the peripubertal time to
the time of clinical examination in the group of women with
hyperandrogenemia of other aetiology (-21.37%) was observed compared to
women with NC-CAH (P<0.001). Conclusion We have shown that acne persists
from peripubertal period to adult life in NC-CAH women whereas it tends
to diminish in women with hyperandrogenemia of other aetiology. Acne is
a prominent finding in women with NC-CAH. Serum concentrations of 17-OHP
after ACTH stimulation (17-OHP6O) should be investigated in women with
persistent acne in adult life."
}