@article{3160262,
    title = "Weight change later in life and colon and rectal cancer risk in
participants in the EPIC-PANACEA study",
    author = "Bisschop, Charlotte N. Steins and van Gils, Carla H. and Emaus, Marleen and J. and Bueno-de-Mesquita, H. Bas and Monninkhof, Evelyn M. and Boeing, and Heiner and Aleksandrova, Krasmira and Jenab, Mazda and Norat, Teresa and and Riboli, Elio and Boutron-Ruault, Marie-Christine and Fagherazzi, Guy and and Racine, Antoine and Palli, Domenico and Krogh, Vittorio and Tumino, and Rosario and Naccarati, Alessio and Mattiello, Amalia and Vicente and Argueeles, Marcial and Jose Sanchez, Maria and Jose Tormo, Maria and and Ardanaz, Eva and Dorronsoro, Miren and Bonet, Catalina and Khaw, Kay-Tee and and Key, Tim and Trichopoulou, Antonia and Orfanos, Philippos and Naska, and Androniki and Kaaks, Rudolph R. and Lukanova, Annekatrin and Pischon, and Tobias and Ljuslinder, Ingrid and Jirstrom, Karin and Ohlsson, Bodil and and Overvad, Kim and Berentzen, Tina Landsvig and Halkjaer, Jytte and and Tjonneland, Anne and Weiderpass, Elisabete and Skeie, Guri and Braaten, and Tonje and Siersema, Peter D. and Freisling, Heinz and Ferrari, Pietro and and Peeters, Petra H. M. and May, Anne M.",
    journal = "AMERICAN JOURNAL OF CLINICAL NUTRITION",
    year = "2014",
    volume = "99",
    number = "1",
    pages = "139-147",
    publisher = "Oxford University Press",
    issn = "0002-9165",
    doi = "10.3945/ajcn.113.066530",
    abstract = "Background: A moderate association exists between body mass index (BMI)
and colorectal cancer. Less is known about the effect of weight change.
Objective: We investigated the relation between BMI and weight change
and subsequent colon and rectal cancer risk.
Design: This was studied among 328,781 participants in the prospective
European Prospective Investigation into Cancer Physical Activity,
Nutrition, Alcohol, Cessation of Smoking, Eating study (mean age: 50 y).
Body weight was assessed at recruitment and on average 5 y later.
Self-reported weight change (kg/y) was categorized in sex-specific
quintiles, with quintiles 2 and 3 combined as the reference category
(men: -0.6 to 0.3 kg/y; women: -0.4 to 0.4 kg/y). In the subsequent
years, participants were followed for the occurrence of colon and rectal
cancer (median period: 6.8 y). Multivariable Cox proportional hazards
regression analyses were used to study the association.
Results: A total of 1261 incident colon cancer and 747 rectal cancer
cases were identified. ME at recruitment was statistically significantly
associated with colon cancer risk in men (HR: 1.04; 95% CI: 1.02,
1.07). Moderate weight gain (quintile 4) in men increased risk further
(HR: 1.32; 95% CI: 1.04, 1.68), but this relation did not show a clear
trend. In women, BMI or weight gain was not related to subsequent risk
of colon cancer. No statistically significant associations for weight
loss and colon cancer or for BMI and weight changes and rectal cancer
were found.
Conclusions: BMI attained at adulthood was associated with colon cancer
risk. Subsequent weight gain or loss was not related to colon or rectal
cancer risk in men or women."
}