@article{3161019,
    title = "Genome-wide association study identifies multiple loci associated with
bladder cancer risk",
    author = "Figueroa, Jonine D. and Ye, Yuanqing and Siddiq, Afshan and and Garcia-Closas, Montserrat and Chatterjee, Nilanjan and Prokunina-Olsson, and Ludmila and Cortessis, Victoria K. and Kooperberg, Charles and Cussenot, and Olivier and Benhamou, Simone and Prescott, Jennifer and Porru, Stefano and and Dinney, Colin P. and Malats, Nuria and Baris, Dalsu and Purdue, Mark and and Jacobs, Eric J. and Albanes, Demetrius and Wang, Zhaoming and Deng, and Xiang and Chung, Charles C. and Tang, Wei and Bueno-De-Mesquita, H. Bas and and Trichopoulos, Dimitrios and Ljungberg, Borje and Clavel-Chapelon, and Frangoise and Weiderpass, Elisabete and Krogh, Vittorio and Dorronsoro, and Miren and Travis, Ruth and Tjonneland, Anne and Brenan, Paul and and Chang-Claude, Jenny and Riboli, Elio and Conti, David and and Gago-Dominguez, Manuela and Stern, Mariana C. and Pike, Malcolm C. and and Van den Berg, David and Yuan, Jian-Min and Hohensee, Chancellor and and Rodabough, Rebecca and Cancel-Tassin, Geraldine and Roupret, Morgan and and Comperat, Eva and Chen, Constance and De Vivo, Immaculata and and Giovannucci, Edward and Hunter, David J. and Kraft, Peter and Lindstrom, and Sara and Carta, Angela and Pavanello, Sofia and Arici, Cecilia and and Mastrangelo, Giuseppe and Kamat, Ashish M. and Lerner, Seth P. and and Grossman, H. Barton and Lin, Jie and Gu, Jian and Pu, Xia and and Hutchinson, Amy and Burdette, Laurie and Wheeler, William and Kogevinas, and Manolis and Tardon, Adonina and Serra, Consol and Carrato, Alfredo and and Garcia-Closas, Reina and Lloreta, Josep and Schwenn, Molly and Karagas, and Margaret R. and Johnson, Alison and Schned, Alan and Armenti, Karla R. and and Hosain, G. M. and Andriole, Jr., Gerald and Grubb, III, Robert and and Black, Amanda and Diver, W. Ryan and Gapstur, Susan M. and Weinstein, and Stephanie J. and Virtamo, Jarmo and Haiman, Chris A. and Landi, Maria T. and and Caporaso, Neil and Fraumeni, Jr., Joseph F. and Vineis, Paolo and and Wu, Xifeng and Silverman, Debra T. and Chanock, Stephen and Rothman, and Nathaniel",
    journal = "Human Molecular Genetics",
    year = "2014",
    volume = "23",
    number = "5",
    pages = "1387-1398",
    publisher = "Oxford University Press",
    issn = "0964-6906, 1460-2083",
    doi = "10.1093/hmg/ddt519",
    abstract = "Candidate gene and genome-wide association studies (GWAS) have
identified 11 independent susceptibility loci associated with bladder
cancer risk. To discover additional risk variants, we conducted a new
GWAS of 2422 bladder cancer cases and 5751 controls, followed by a
meta-analysis with two independently published bladder cancer GWAS,
resulting in a combined analysis of 6911 cases and 11 814 controls of
European descent. TaqMan genotyping of 13 promising single nucleotide
polymorphisms with P < 1 x 10(-5) was pursued in a follow-up set of 801
cases and 1307 controls. Two new loci achieved genome-wide statistical
significance: rs10936599 on 3q26.2 (P = 4.53 x 10(-9)) and rs907611 on
11p15.5 (P = 4.11 x 10(-8)). Two notable loci were also identified that
approached genome-wide statistical significance: rs6104690 on 20p12.2 (P
= 7.13 x 10(-7)) and rs4510656 on 6p22.3 (P = 6.98 x 10(-7)); these
require further studies for confirmation. In conclusion, our study has
identified new susceptibility alleles for bladder cancer risk that
require fine-mapping and laboratory investigation, which could further
understanding into the biological underpinnings of bladder
carcinogenesis."
}