@article{3161655,
    title = "Dietary intake of acrylamide and esophageal cancer risk in the European
Prospective Investigation into Cancer and Nutrition cohort",
    author = "Lujan-Barroso, Leila and Alberto Gonzalez, Carlos and Slimani, Nadia and and Obon-Santacana, Mireia and Ferrari, Pietro and Freisling, Heinz and and Overvad, Kim and Clavel-Chapelon, Francoise and Boutron-Ruault, and Marie-Christine and Racine, Antoine and Katzke, Verena and Kuehn, Tilman and and Tjonneland, Anne and Olsen, Anja and Ramon Quiros, J. and and Sanchez-Cantalejo, Emilio and Amiano, Pilar and Navarro, Carmen and and Barricarte, Aurelio and Khaw, Kay-Tee and Wareham, Nick and Travis, Ruth and C. and Trichopoulou, Antonia and Bamia, Christina and Benetou, Vassiliki and and Saieva, Calogero and Grioni, Sara and Tumino, Rosario and Vineis, and Paolo and Mattiello, Amalia and Bueno-de-Mesquita, H. Bas and Siersema, and Peter D. and Numans, Mattijs E. and Peeters, Petra H. and Ericson, and Ulrika and Wirfaelt, Elisabet and Sund, Malin and Johansson, Mattias and and Weiderpass, Elisabete and Skeie, Guri and Riboli, Elio and Boeing, and Heiner and Duell, Eric J.",
    journal = "Cancer Causes and Control",
    year = "2014",
    volume = "25",
    number = "5",
    pages = "639-646",
    publisher = "Springer-Verlag",
    issn = "0957-5243, 1573-7225",
    doi = "10.1007/s10552-014-0359-5",
    keywords = "Esophageal cancer; Esophageal squamous cell carcinoma; Esophageal
adenocarcinoma; Acrylamide intake; Cohort; Nutrition",
    abstract = "The relation between dietary acrylamide intake and esophageal cancer
(EC) risk, including esophageal adenocarcinoma (EAC) and esophageal
squamous cell carcinoma (ESCC), has not been consistent. We evaluated
the association between dietary acrylamide intake and EAC, ESCC, and
overall EC in the European Prospective Investigation into Cancer and
Nutrition (EPIC) cohort.
Multivariate Cox proportional hazards models were used to estimate the
HR and 95 % confidence interval (95 % CI). Since nonlinear relations
were observed, HRs were displayed for quartiles of acrylamide intake in
mu g per day.
After a mean follow-up of 11 years, 341 EC were identified, 142 of which
were EAC, 176 ESCC, and 23 other histological types or not specified. An
increase in EC risk was observed in the second and third quartiles
(HRQ2vsQ1 1.75, 95 % CI 1.12-2.74; HRQ3vsQ1 1.66, 95 % CI 1.05-2.61),
but not in the fourth quartile, and there was no evidence for a linear
dose-response trend. HRs were similarly elevated but not statistically
significant when ESCC and EAC were analyzed separately, due to the small
number of cases observed. No associations were observed when quartiles
were based on energy-adjusted acrylamide intake.
In the EPIC cohort, an association between estimated dietary acrylamide
intake and an increased risk of developing EC was observed in the middle
quartiles but not in the highest quartile; however, results from other
larger cohorts or consortia, and results from biomarker studies, might
add to the evidence provided by this analysis, suggesting that
acrylamide is not an important risk factor for EC."
}