@article{3162558,
    title = "Genome-wide interaction study of smoking and bladder cancer risk",
    author = "Figueroa, Jonine D. and Han, Summer S. and Garcia-Closas, Montserrat and and Baris, Dalsu and Jacobs, Eric J. and Kogevinas, Manolis and Schwenn, and Molly and Malats, Nuria and Johnson, Alison and Purdue, Mark P. and and Caporaso, Neil and Landi, Maria Teresa and Prokunina-Olsson, Ludmila and and Wang, Zhaoming and Hutchinson, Amy and Burdette, Laurie and Wheeler, and William and Vineis, Paolo and Siddiq, Afshan and Cortessis, Victoria K. and and Kooperberg, Charles and Cussenot, Olivier and Benhamou, Simone and and Prescott, Jennifer and Porru, Stefano and Bueno-de-Mesquita, H. Bas and and Trichopoulos, Dimitrios and Ljungberg, Boerje and Clavel-Chapelon, and Franoise and Weiderpass, Elisabete and Krogh, Vittorio and Dorronsoro, and Miren and Travis, Ruth and Tjonneland, Anne and Brenan, Paul and and Chang-Claude, Jenny and Riboli, Elio and Conti, David and and Gago-Dominguez, Manuela and Stern, Mariana C. and Pike, Malcolm C. and and Van den Berg, David and Yuan, Jian-Min and Hohensee, Chancellor and and Rodabough, Rebecca and Cancel-Tassin, Geraldine and Roupret, Morgan and and Comperat, Eva and Chen, Constance and De Vivo, Immaculata and and Giovannucci, Edward and Hunter, David J. and Kraft, Peter and Lindstrom, and Sara and Carta, Angela and Pavanello, Sofia and Arici, Cecilia and and Mastrangelo, Giuseppe and Karagas, Margaret R. and Schned, Alan and and Armenti, Karla R. and Hosain, G. M. Monawar and Haiman, Chris A. and and Fraumeni, Jr., Joseph F. and Chanock, Stephen J. and Chatterjee, and Nilanjan and Rothman, Nathaniel and Silverman, Debra T.",
    journal = "Journal of Carcinogenesis",
    year = "2014",
    volume = "35",
    number = "8",
    pages = "1737-1744",
    publisher = "Oxford University Press",
    issn = "1477-3163",
    doi = "10.1093/carcin/bgu064",
    abstract = "Bladder cancer is a complex disease with known environmental and genetic
risk factors. We performed a genome-wide interaction study (GWAS) of
smoking and bladder cancer risk based on primary scan data from 3002
cases and 4411 controls from the National Cancer Institute Bladder
Cancer GWAS. Alternative methods were used to evaluate both additive and
multiplicative interactions between individual single nucleotide
polymorphisms (SNPs) and smoking exposure. SNPs with interaction P
values < 5 x 10(-5) were evaluated further in an independent dataset of
2422 bladder cancer cases and 5751 controls. We identified 10 SNPs that
showed association in a consistent manner with the initial dataset and
in the combined dataset, providing evidence of interaction with tobacco
use. Further, two of these novel SNPs showed strong evidence of
association with bladder cancer in tobacco use subgroups that approached
genome-wide significance. Specifically, rs1711973 (FOXF2) on 6p25.3 was
a susceptibility SNP for never smokers [combined odds ratio (OR) =
1.34, 95% confidence interval (CI) = 1.20-1.50, P value = 5.18 x
10(-7)]; and rs12216499 (RSPH3-TAGAP-EZR) on 6q25.3 was a susceptibility
SNP for ever smokers (combined OR = 0.75, 95% CI = 0.67-0.84, P value =
6.35 x 10-7). In our analysis of smoking and bladder cancer, the tests
for multiplicative interaction seemed to more commonly identify
susceptibility loci with associations in never smokers, whereas the
additive interaction analysis identified more loci with associations
among smokers-including the known smoking and NAT2 acetylation
interaction. Our findings provide additional evidence of
gene-environment interactions for tobacco and bladder cancer."
}