@article{3163132,
    title = "Short-term beat-to-beat but not ambulatory blood pressure variability is
correlated to carotid intima-media thickness",
    author = "Manios, Efstathios and Michas, Fotios and Stamatelopoulos, Kimon and and Barlas, Gerasimos and Koroboki, Eleni and Tsouma, Iliana and Vemmos, and Konstantinos and Zakopoulos, Nikolaos",
    journal = "Blood Pressure Monitoring",
    year = "2014",
    volume = "19",
    number = "5",
    pages = "288-293",
    publisher = "Lippincott, Williams & Wilkins",
    issn = "1359-5237, 1473-5725",
    doi = "10.1097/MBP.0000000000000062",
    keywords = "ambulatory blood pressure; beat-to-beat blood pressure; blood pressure
variability; common carotid artery intima-media thickness",
    abstract = "Objectives Several studies have shown that blood pressure (BP)
variability derived from ambulatory blood pressure monitoring (ABPM) is
associated with target organ damage development. However, the use of
discontinuous ABPM to assess rapid BP changes is unavoidably limited by
the long frequency at which automated measures are scheduled. The aim of
our study was to identify whether ABPM-derived variability or short-term
beat-to-beat BP variability is better associated with common carotid
artery intima-media thickness (CCA-IMT) in untreated hypertensive
patients.
Participants and methods A total of 85 individuals underwent 24-h ABPM
and carotid artery ultrasonographic measurements. Three 5-min recordings
of noninvasive beat-to-beat BP were made under standardized conditions.
The time rate (TR) of BP variation was defined as the first derivative
of the BP values against time. The study population was divided into
normotensive and hypertensive participants according to 24-h BP values
(130/80 mmHg).
Results Hypertensive patients (n = 45) presented significantly higher TR
of 24-h BP variation (P < 0.05) and beat-to-beat TR of systolic BP
variation (P < 0.05) than their normotensive counterparts (n = 40). The
multivariate linear regression analyses in hypertensive patients showed
significant and independent associations of CCA-IMT with the following
factors: 24-h systolic blood pressure (SBP) (B = 0.065, 95% confidence
interval: 0.006-0.124; P = 0.033) and TR of beat-to-beat SBP (B = 0.013,
95% confidence interval: 0.005-0.020; P = 0.002). A 10 mmHg/min
increase in the TR beat-to-beat SBP variation correlated to an increase
of 0.013 mm in the CCA-IMT values.
Conclusion Short-term beat-to-beat TR of BP variation is associated
independently with CCA-IMT values and presents a better predictor of
target organ damage involvement than BP variability indexes derived from
ABPM. (C) 2014 Wolters Kluwer Health broken vertical bar Lippincott
Williams & Wilkins."
}