@article{3163740,
    title = "Prediagnostic immunoglobulin E levels and risk of chronic lymphocytic
leukemia, other lymphomas and multiple myeloma-results of the European
Prospective Investigation into Cancer and Nutrition",
    author = "Nieters, Alexandra and Luczynska, Anna and Becker, Susen and Becker, and Nikolaus and Vermeulen, Roel and Overvad, Kim and Aleksandrova, and Krasimira and Boeing, Heiner and Lagiou, Pagona and Trichopoulos, and Dimitrios and Trichopoulou, Antonia and Krogh, Vittorio and Masala, and Giovanna and Panico, Salvatore and Tumino, Rosario and Sacerdote, and Carlotta and Bueno-de-Mesquita, Bas and Jeurnink, Suzanne M. and and Weiderpass, Elisabete and Ardanaz, Eva and Chirlaque, Maria-Dolores and and Sanchez, Maraia-Jose and Sanchez, Soledad and Borgquist, Signe and Butt, and Salma and Melin, Beatrice and Spaeth, Florentin and Rinaldi, Sabina and and Brennan, Paul and Kelly, Rachel S. and Riboli, Elio and Vineis, Paolo and and Kaaks, Rudolf",
    journal = "Journal of Carcinogenesis",
    year = "2014",
    volume = "35",
    number = "12",
    pages = "2716-2722",
    publisher = "Oxford University Press",
    issn = "1477-3163",
    doi = "10.1093/carcin/bgu188",
    abstract = "Previous epidemiological studies suggest an inverse association between
allergies, marked by elevated immunoglobulin (Ig) E levels, and
non-Hodgkin lymphoma (NHL) risk. The evidence, however, is inconsistent
and prospective data are sparse. We examined the association between
prediagnostic total (low: < 20; intermediate: 20-100; high > 100 kU/l)
and specific IgE (negative: < 0.35; positive >= 0.35 kU/I)
concentrations against inhalant antigens and lymphoma risk in a study
nested within the European Prospective Investigation into Cancer and
Nutrition cohort. A total of 1021 incident cases and matched controls of
NHL, multiple myeloma (MM) and Hodgkin lymphoma with a mean follow-up
time of 7 years were investigated. Multivariate-adjusted odds ratios
(ORs) with 95% confidence intervals (CI) were calculated by conditional
logistic regression. Specific IgE was not associated with the risk of
MM, B-cell NHL and B-cell NHL subtypes. In contrast, total IgE levels
were inversely associated with the risk of MM [high level: OR = 0.40
(95% CI = 0.21-0.79)] and B-cell NHL [intermediate level: OR = 0.68
(95% CI = 0.53-0.88); high level: OR = 0.62 (95% CI = 0.44-0.86)],
largely on the basis of a strong inverse association with chronic
lymphocytic leukemia [CLL; intermediate level: OR = 0.49 (95% CI =
0.30-0.80); high level: OR = 0.13 (95% CI = 0.05-0.35)] risk. The
inverse relationship for CLL remained significant for those diagnosed 5
years after baseline. The findings of this large prospective study
demonstrated significantly lower prediagnostic total IgE levels among
CLL and MM cases compared with matched controls. This corresponds to the
clinical immunodeficiency state often observed in CLL patients prior to
diagnosis. No support for an inverse association between prediagnostic
levels of specific IgE and NHL risk was found."
}