@article{3164602, title = "The present and future disease burden of hepatitis C virus (HCV) infections with today's treatment paradigm - volume 2", author = "Hatzakis, A. and Chulanov, V. and Gadano, A. C. and Bergin, C. and and Ben-Ari, Z. and Mossong, J. and Schreter, I. and Baatarkhuu, O. and and Acharya, S. and Aho, I. and Anand, A. C. and Andersson, M. I. and and Arendt, V. and Arkkila, P. and Barclay, K. and Bessone, F. and Blach, S. and and Blokhina, N. and Brunton, C. R. and Choudhuri, G. and Cisneros, L. and and Croes, E. A. and Dahgwahdorj, Y. A. and Dalgard, O. and Daruich, J. and R. and Dashdorj, N. R. and Davaadorj, D. and de Knegt, R. J. and de and Vree, M. and Estes, C. and Flisiak, R. and Gane, E. and Gower, E. and and Halota, W. and Henderson, C. and Hoffmann, P. and Hornell, J. and and Houlihan, D. and Hrusovsky, S. and Jarcuska, P. and Kershenobich, D. and and Kostrzewska, K. and Kristian, P. and Leshno, M. and Lurie, Y. and and Mahomed, A. and Mamonova, N. and Mendez-Sanchez, N. and Norris, S. and and Nurmukhametova, E. and Nymadawa, P. and Oltman, M. and Oyunbileg, J. and and Oyunsuren, Ts. and Papatheodoridis, G. and Pimenov, N. and and Prabdial-Sing, N. and Prins, M. and Radke, S. and Rakhmanova, A. and and Razavi-Shearer, K. and Reesink, H. W. and Ridruejo, E. and Safadi, R. and and Sagalova, O. and Sanchez Avila, J. F. and Sanduijav, R. and and Saraswat, V. and Seguin-Devaux, C. and Shah, S. R. and Shestakova, I. and and Shevaldin, A. and Shibolet, O. and Silva, M. O. and Sokolov, S. and and Sonderup, M. and Souliotis, K. and Spearman, C. W. and Staub, T. and and Stedman, C. and Strebkova, E. A. and Struck, D. and Sypsa, V. and and Tomasiewicz, K. and Undram, L. and van der Meer, A. J. and van Santen, and D. and Veldhuijzen, I. and Villamil, F. G. and Willemse, S. and and Zuckerman, E. and Zuure, F. R. and Puri, P. and Razavi, H.", journal = "Journal of Viral Hepatitis", year = "2015", volume = "22", number = "1", pages = "26-45", publisher = "Wiley", issn = "1352-0504, 1365-2893", doi = "10.1111/jvh.12351", keywords = "diagnosis; disease burden; epidemiology; HCV; hepatitis C; incidence; mortality; prevalence; treatment", abstract = "Morbidity and mortality attributable to chronic hepatitis C virus (HCV) infection are increasing in many countries as the infected population ages. Models were developed for 15 countries to quantify and characterize the viremic population, as well as estimate the number of new infections and HCV related deaths from 2013 to 2030. Expert consensus was used to determine current treatment levels and outcomes in each country. In most countries, viremic prevalence has already peaked. In every country studied, prevalence begins to decline before 2030, when current treatment levels were held constant. In contrast, cases of advanced liver disease and liver related deaths will continue to increase through 2030 in most countries. The current treatment paradigm is inadequate if large reductions in HCV related morbidity and mortality are to be achieved." }