@article{3164604, title = "Strategies to manage hepatitis C virus (HCV) infection disease burden - volume 2", author = "Gane, E. and Kershenobich, D. and Seguin-Devaux, C. and Kristian, P. and and Aho, I. and Dalgard, O. and Shestakova, I. and Nymadawa, P. and Blach, and S. and Acharya, S. and Anand, A. C. and Andersson, M. I. and Arendt, V. and and Arkkila, P. and Baatarkhuu, O. and Barclay, K. and Ben-Ari, Z. and and Bergin, C. and Bessone, F. and Blokhina, N. and Brunton, C. R. and and Choudhuri, G. and Chulanov, V. and Cisneros, L. and Croes, E. A. and and Dahgwahdorj, Y. A. and Daruich, J. R. and Dashdorj, N. R. and Davaadorj, and D. and de Knegt, R. J. and de Vree, M. and Gadano, A. C. and Gower, E. and and Halota, W. and Hatzakis, A. and Henderson, C. and Hoffmann, P. and and Hornell, J. and Houlihan, D. and Hrusovsky, S. and Jarcuska, P. and and Kostrzewska, K. and Leshno, M. and Lurie, Y. and Mahomed, A. and and Mamonova, N. and Mendez-Sanchez, N. and Mossong, J. and Norris, S. and and Nurmukhametova, E. and Oltman, M. and Oyunbileg, J. and Oyunsuren, Ts. and and Papatheodoridis, G. and Pimenov, N. and Prins, M. and Puri, P. and and Radke, S. and Rakhmanova, A. and Razavi, H. and Razavi-Shearer, K. and and Reesink, H. W. and Ridruejo, E. and Safadi, R. and Sagalova, O. and and Sanchez Avila, J. F. and Sanduijav, R. and Saraswat, V. and Schreter, I. and and Shah, S. R. and Shevaldin, A. and Shibolet, O. and Silva, M. O. and and Sokolov, S. and Sonderup, M. and Souliotis, K. and Spearman, C. W. and and Staub, T. and Stedman, C. and Strebkova, E. A. and Struck, D. and Sypsa, and V. and Tomasiewicz, K. and Undram, L. and van der Meer, A. J. and van and Santen, D. and Veldhuijzen, I. and Villamil, F. G. and Willemse, S. and and Zuckerman, E. and Zuure, F. R. and Prabdial-Sing, N. and Flisiak, R. and and Estes, C.", journal = "Journal of Viral Hepatitis", year = "2015", volume = "22", number = "1", pages = "46-73", publisher = "Wiley", issn = "1352-0504, 1365-2893", doi = "10.1111/jvh.12352", keywords = "diagnosis; disease burden; epidemiology; HCV; hepatitis C; incidence; mortality; prevalence; scenarios; treatment", abstract = "The hepatitis C virus (HCV) epidemic was forecasted through 2030 for 15 countries, and the relative impact of two scenarios was considered: (i) increased treatment efficacy while holding the treated population constant and (ii) increased treatment efficacy and increased annual treated population. Increasing levels of diagnosis and treatment, in combination with improved treatment efficacy, were critical for achieving substantial reductions in disease burden. In most countries, the annual treated population had to increase several fold to achieve the largest reductions in HCV-related morbidity and mortality. This suggests that increased capacity for screening and treatment will be critical in many countries. Birth cohort screening is a helpful tool for maximizing resources. In most of the studied countries, the majority of patients were born between 1945 and 1985." }