@article{3164699,
    title = "Insulin-like growth factor I and risk of epithelial invasive ovarian
cancer by tumour characteristics: results from the EPIC cohort",
    author = "Ose, J. and Fortner, R. T. and Schock, H. and Peeters, P. H. and and Onland-Moret, N. C. and Bueno-de-Mesquita, H. B. and Weiderpass, E. and and Gram, I. T. and Overvad, K. and Tjonneland, A. and Dossus, L. and and Fournier, A. and Baglietto, L. and Trichopoulou, A. and Benetou, V. and and Trichopoulos, D. and Boeing, H. and Masala, G. and Krogh, V. and and Matiello, A. and Tumino, R. and Popovic, M. and Obon-Santacana, M. and and Larranaga, N. and Ardanaz, E. and Sanchez, M-J and Menendez, V. and and Chirlaque, M-D and Travis, R. C. and Khaw, K-T and Braendstedt, J. and and Idahl, A. and Lundin, E. and Rinaldi, S. and Kuhn, E. and Romieu, I. and and Gunter, M. J. and Merritt, M. A. and Riboli, E. and Kaaks, R.",
    journal = "British Journal of Cancer",
    year = "2015",
    volume = "112",
    number = "1",
    pages = "162-166",
    publisher = "Nature Publishing Group",
    issn = "0007-0920, 1532-1827",
    doi = "10.1038/bjc.2014.566",
    keywords = "IGF-I; ovarian cancer; histological subtypes; carcinogenesis; type
I/type II; dualistic pathway",
    abstract = "Background: Prospective studies on insulin-like growth factor I (IGF-I)
and epithelial ovarian cancer (EOC) risk are inconclusive. Data suggest
risk associations vary by tumour characteristics.
Methods: We conducted a nested case-control study in the European
Prospective Investigation into Cancer and Nutrition (EPIC) to evaluate
IGF-I concentrations and EOC risk by tumour characteristics (n = 565
cases). Multivariable conditional logistic regression models were used
to estimate associations.
Results: We observed no association between IGF-I and EOC overall or by
tumour characteristics.
Conclusions: In the largest prospective study to date was no association
between IGF-I and EOC risk. Pre-diagnostic serum IGF-I concentrations
may not influence EOC risk."
}