@article{3164963,
    title = "Plasma Elaidic Acid Level as Biomarker of Industrial Trans Fatty Acids
and Risk of Weight Change: Report from the EPIC Study",
    author = "Chajes, Veronique and Biessy, Carine and Ferrari, Pietro and Romieu, and Isabelle and Freisling, Heinz and Huybrechts, Inge and Scalbert, and Augustin and de Mesquita, Bas Bueno and Romaguera, Dora and Gunter, Marc and J. and Vineis, Paolo and Hansen, Camilla Plambeck and Jakobsen, Marianne and Uhre and Clavel-Chapelon, Francoise and Fagherazzi, Guy and and Boutron-Ruault, Marie-Christine and Katzke, Verana and Neamat-Allah, and Jasmine and Boeing, Heiner and Bachlechner, Ursula and Trichopoulou, and Antonia and Naska, Androniki and Orfanos, Philippos and Pala, Valeria and and Masala, Giovanna and Mattiello, Amalia and Skeie, Guri and and Weiderpass, Elisabete and Agudo, Antonio and Maria Huerta, Jose and and Ardanaz, Eva and Jose Sanchez, Maria and Dorronsoro, Miren and Ramon and Quiros, Jose and Johansson, Ingegerd and Winkvist, Anna and Sonested, and Emily and Key, Tim and Khaw, Kay-Tee and Wareham, Nicolas J. and and Peeters, Petra H. M. and Slimani, Nadia",
    journal = "PLOS ONE",
    year = "2015",
    volume = "10",
    number = "2",
    publisher = "Public Library of Science",
    doi = "10.1371/journal.pone.0118206",
    abstract = "Background
Few epidemiological studies have examined the association between
dietary trans fatty acids and weight gain, and the evidence remains
inconsistent. The main objective of the study was to investigate the
prospective association between biomarker of industrial trans fatty
acids and change in weight within the large study European Prospective
Investigation into Cancer and Nutrition ( EPIC) cohort.
Methods
Baseline plasma fatty acid concentrations were determined in a
representative EPIC sample from the 23 participating EPIC centers. A
total of 1,945 individuals were followed for a median of 4.9 years to
monitor weight change. The association between elaidic acid level and
percent change of weight was investigated using a multinomial logistic
regression model, adjusted by length of follow- up, age, energy,
alcohol, smoking status, physical activity, and region.
Results
In women, doubling elaidic acid was associated with a decreased risk of
weight loss ( odds ratio ( OR) = 0.69, 95% confidence interval ( CI) =
0.55- 0.88, p = 0.002) and a trend was observed with an increased risk
of weight gain during the 5- year follow- up ( OR = 1.23, 95% CI =
0.97- 1.56, p = 0.082) ( p- trend<. 0001). In men, a trend was observed
for doubling elaidic acid level and risk of weight loss ( OR = 0.82,
95% CI = 0.66- 1.01, p = 0.062) while no significant association was
found with risk of weight gain during the 5- year follow- up ( OR =
1.08, 95% CI = 0.88- 1.33, p = 0.454). No association was found for
saturated and cismonounsaturated fatty acids.
Conclusions
These data suggest that a high intake of industrial trans fatty acids
may decrease the risk of weight loss, particularly in women. Prevention
of obesity should consider limiting the consumption of highly processed
foods, the main source of industrially- produced trans fatty acids."
}