@article{3167568,
    title = "Pre-diagnostic polyphenol intake and breast cancer survival: the
European Prospective Investigation into Cancer and Nutrition (EPIC)
cohort",
    author = "Kyro, Cecilie and Zamora-Ros, Raul and Scalbert, Augustin and and Tjonneland, Anne and Dossus, Laure and Johansen, Christoffer and and Bidstrup, Pernille Envold and Weiderpass, Elisabete and Christensen, and Jane and Ward, Heather and Aune, Dagfinn and Riboli, Elio and His, and Mathilde and Clavel-Chapelon, Francoise and Baglietto, Laura and Katzke, and Verena and Kuehn, Tilman and Boeing, Heiner and Floegel, Anna and and Overvad, Kim and Lasheras, Cristina and Travier, Noemie and Sanchez, and Maria-Jose and Amiano, Pilar and Chirlaque, Maria-Dolores and Ardanaz, and Eva and Khaw, Kay-Tee and Wareham, Nick and Perez-Cornago, Aurora and and Trichopoulou, Antonia and Lagiou, Pagona and Vasilopoulou, Effie and and Masala, Giovanna and Grioni, Sara and Berrino, Franco and Tumino, and Rosario and Sacerdote, Carlotta and Mattiello, Amalia and and Bueno-de-Mesquita, H. B(as). and Peeters, Petra H. and van Gils, Carla and and Borgquist, Signe and Butt, Salma and Zeleniuch-Jacquotte, Anne and and Sund, Malin and Hjartaker, Anette and Skeie, Guri and Olsen, Anja and and Romieu, Isabelle",
    journal = "Breast Cancer Research and Treatment",
    year = "2015",
    volume = "154",
    number = "2",
    pages = "389-401",
    publisher = "Springer-Verlag",
    issn = "0167-6806, 1573-7217",
    doi = "10.1007/s10549-015-3595-9",
    keywords = "Breast cancer; Survivorship; Polyphenols; Phytoestrogens; Lignans",
    abstract = "The aim was to investigate the association between pre-diagnostic
intakes of polyphenol classes (flavonoids, lignans, phenolic acids,
stilbenes, and other polyphenols) in relation to breast cancer survival
(all-cause and breast cancer-specific mortality). We used data from the
European Prospective Investigation into Cancer and Nutrition cohort.
Pre-diagnostic usual diet was assessed using dietary questionnaires, and
polyphenol intakes were estimated using the Phenol-Explorer database. We
followed 11,782 breast cancer cases from time of diagnosis until death,
end of follow-up or last day of contact. During a median of 6 years,
1482 women died (753 of breast cancer). We related polyphenol intake to
all-cause and breast cancer-specific mortality using Cox proportional
hazard models with time since diagnosis as underlying time and strata
for age and country. Among postmenopausal women, an intake of lignans in
the highest versus lowest quartile was related to a 28 % lower risk of
dying from breast (adjusted model: HR, quartile 4 vs. quartile 1, 0.72,
95 % CI 0.53; 0.98). In contrast, in premenopausal women, a positive
association between lignan intake and all-cause mortality was found
(adjusted model: HR, quartile 4 vs. quartile 1, 1.63, 95 % CI 1.03;
2.57). We found no association for other polyphenol classes. Intake of
lignans before breast cancer diagnosis may be related to improved
survival among postmenopausal women, but may on the contrary worsen the
survival for premenopausal women. This suggests that the role of
phytoestrogens in breast cancer survival is complex and may be dependent
of menopausal status."
}