@article{3168502,
    title = "Changes in BODE Quartiles After Pulmonary Rehabilitation Do Not Predict
2-Year Survival in Patients With COPD",
    author = "Kavoura, Paraskevi and Kostikas, Konstantinos and Tselebis, Athanasios and and Bratis, Dionysios and Kosmas, Epaminondas and Alchanatis, Manos and and Koulouris, Nikolaos G. and Bakakos, Petros and Loukides, Stelios",
    journal = "Journal of Cardiopulmonary Rehabilitation and Prevention",
    year = "2016",
    volume = "36",
    number = "1",
    pages = "62-67",
    publisher = "Lippincott, Williams & Wilkins",
    issn = "1932-7501",
    doi = "10.1097/HCR.0000000000000157",
    keywords = "BODE index; COPD; pulmonary rehabilitation; survival",
    abstract = "PURPOSE: Pulmonary rehabilitation (PR) has well documented positive
effects in patients with chronic obstructive pulmonary disease (COPD).
The BODE (body mass index, airflow obstruction, dyspnea, and exercise)
index reflects the multicomponent nature of COPD. We aimed to determine
whether changes in BODE quartiles after a PR program might affect 2-year
survival and which characteristics drive changes in BODE quartiles after
PR intervention.
METHODS: Ninety-five patients with COPD participated in a PR program.
The BODE index and anxiety, depression, and quality of life
questionnaires were completed before and after the PR program. Five-year
survival was recorded for all patients, irrespective of changes in BODE
quartiles.
RESULTS: Up to 62% of patients with COPD had an improvement in the BODE
index, whereas 42% of patients had a change in BODE quartile. Survival
did not differ between patients who did not and who did show an
improvement in BODE quartiles, despite a trend in favor of the latter
(log-rank P=.202). Similar results were observed for patients who did
and did not demonstrate a change in the BODE index >= 2 (log-rank
P=.679). Significant changes in BODE quartiles were mainly attributed to
the duration of the disease, current smoking status, hospitalization
rate in the previous year, and the presence of poorer quality of life,
as well as to anxiety and depression at baseline.
CONCLUSIONS: Pulmonary rehabilitation significantly influenced the BODE
index. The significant changes in BODE quartiles were associated with
the duration of the disease, current smoking status, increased
hospitalization rate, poorer quality of life, anxiety, and depression at
baseline, but failed to predict 2-year survival."
}