@article{3168529,
    title = "The Tree of Sirtuins and the Garden of Cardiovascular Youth",
    author = "Katsi, Vasiliki K. and Pavlidis, Antonios N. and Liakos, Charalampos I. and and Marketou, Maria E. and Raftopoulos, Leonidas G. and Alexopoulos, and Nikolaos A. and Makris, Thomas K. and Nihoyannopoulos, Petros and and Tousoulis, Dimitris and Kallikazaros, Ioannis E.",
    journal = "Current Vascular Pharmacology",
    year = "2016",
    volume = "14",
    number = "1",
    pages = "80-87",
    publisher = "BENTHAM SCIENCE PUBL LTD",
    issn = "1570-1611",
    doi = "10.2174/1570161113666150916093902",
    keywords = "Sirtuins; aging; cardiovascular diseases; cancer; apoptosis; oxidative
stress",
    abstract = "Sirtuins (SIRTs) are a class of nicotine adenine dinucleotide
(NAD+)-dependent proteins which participate in numerous molecular
pathways involved in various age-related human diseases, such as type II
diabetes, cardiovascular (CV) diseases and cancer. They have a major
role in apoptosis, inflammation, oxidative stress and metabolism
regulation, traits that have a great impact on CV physiology and
pathology. Their unique profile of NAD+ energy dependency makes them an
appealing target for human intervention in cellular and metabolic
processes. This review focuses on the recent advances of SIRTs research
aiming to shed light on the emerging roles of SIRTs in the
pathophysiology of CV and metabolic diseases."
}