@article{3169140,
    title = "STAT3-Ser/Hes3 Signaling: A New Molecular Component of the
Neuroendocrine System?",
    author = "Nikolakopoulou, P. and Poser, S. W. and Masjkur, J. and de Celis, M. and Fernandez Rubin and Toutouna, L. and Andoniadou, C. L. and McKay, R. D. and and Chrousos, G. and Ehrhart-Bornstein, M. and Bornstein, S. R. and and Androutsellis-Theotokis, A.",
    journal = "Hormone and Metabolic Research",
    year = "2016",
    volume = "48",
    number = "2",
    pages = "77-82",
    publisher = "Georg Thieme Verlag KG",
    issn = "0018-5043, 1439-4286",
    doi = "10.1055/s-0041-111699",
    keywords = "STAT3; Hes3; stem cells",
    abstract = "The endocrine system involves communication among different tissues in
distinct organs, including the pancreas and components of the
Hypothalamic-Pituitary-Adrenal Axis. The molecular mechanisms underlying
these complex interactions are a subject of intense study as they may
hold clues for the progression and treatment of a variety of metabolic
and degenerative diseases. A plethora of signaling pathways, activated
by hormones and other endocrine factors have been implicated in this
communication. Recent advances in the stem cell field introduce a new
level of complexity: adult progenitor cells appear to utilize distinct
signaling pathways than the more mature cells in the tissue they
co-reside. It is therefore important to elucidate the signal
transduction requirements of adult progenitor cells in addition to those
of mature cells. Recent evidence suggests that a common non-canonical
signaling pathway regulates adult progenitors in several different
tissues, rendering it as a potentially valuable starting point to
explore their biology. The STAT3-Ser/Hes3 Signaling Axis was first
identified as a major regulator of neural stem cells and, subsequently,
cancer stem cells. In the endocrine/neuroendocrine system, this pathway
operates on several levels, regulating other types of plastic cells: (a)
it regulates pancreatic islet cell function and insulin release; (b)
insulin in turn activates the pathway in broadly distributed neural
progenitors and possibly also hypothalamic tanycytes, cells with
important roles in the control of the adrenal gland; (c) adrenal
progenitors themselves operate this pathway. The STAT3-Ser/Hes3
Signaling Axis therefore deserves additional research in the context of
endocrinology."
}