@article{3169206, title = "Allergen immunotherapy for insect venom allergy: protocol for a systematic review", author = "Dhami, Sangeeta and Nurmatov, Ulugbek and Varga, Eva-Maria and Sturm, and Gunter and Muraro, Antonella and Akdis, Cezmi A. and Antolin-Amerigo, and Dario and Bilo, M. Beatrice and Bokanovic, Danijela and Calderon, Moises and A. and Cichocka-Jarosz, Ewa and Oude Elberink, Joanna N. G. and Gawlik, and Radoslaw and Jakob, Thilo and Kosnik, Mitja and Lange, Joanna and and Mingomataj, Ervin and Mitsias, Dimitris I. and Mosbech, Holger and and Pfaar, Oliver and Pitsios, Constantinos and Pravettoni, Valerio and and Roberts, Graham and Rueeff, Franziska and Sin, Betul Ayse and Sheikh, and Aziz", journal = "Clinical and Translational Allergy", year = "2016", volume = "6", publisher = "BMC", doi = "10.1186/s13601-016-0095-x", keywords = "Allergy; Insect sting; Hymenoptera venom allergy; Insect venom allergy; Allergen immunotherapy; Systemic sting reaction", abstract = "Background: The European Academy of Allergy and Clinical Immunology (EAACI) is in the process of developing the EAACI Guidelines for Allergen Immunotherapy (AIT) for the Management of Insect Venom Allergy. We seek to critically assess the effectiveness, cost-effectiveness and safety of AIT in the management of insect venom allergy. Methods: We will undertake a systematic review, which will involve searching international biomedical databases for published, in progress and unpublished evidence. Studies will be independently screened against pre-defined eligibility criteria and critically appraised using established instruments. Data will be descriptively and, if possible and appropriate, quantitatively synthesised. Discussion: The findings from this review will be used to inform the development of recomendations for EAACI's Guidelines on AIT." }