@article{3174305,
    title = "Prediagnostic circulating concentrations of plasma insulin-like growth
factor-I and risk of lymphoma in the European Prospective Investigation
into Cancer and Nutrition",
    author = "Perez-Cornago, Aurora and Appleby, Paul N. and Tipper, Sarah and Key, and Timothy J. and Allen, Naomi E. and Nieters, Alexandra and Vermeulen, and Roel and Roulland, Sandrine and Casabonne, Delphine and Kaaks, Rudolf and and Fortner, Renee T. and Boeing, Heiner and Trichopoulou, Antonia and and La Vecchia, Carlo and Klinaki, Eleni and Hansen, Louise and Tjonneland, and Anne and Bonnet, Fabrice and Fagherazzi, Guy and Boutron-Ruault, and Marie-Christine and Pala, Valeria and Masala, Giovanna and Sacerdote, and Carlotta and Peeters, Petra H. and Bueno-de-Mesquita, H. B(as) and and Weiderpass, Elisabete and Dorronsoro, Miren and Quiros, J. Ramon and and Barricarte, Aurelio and Gavrila, Diana and Agudo, Antonio and Borgquist, and Signe and Rosendahl, Ann H. and Melin, Beatrice and Wareham, Nick and and Khaw, Kay-Tee and Gunter, Marc and Riboli, Elio and Vineis, Paolo and and Travis, Ruth C.",
    journal = "International Journal  of Cancer",
    year = "2017",
    volume = "140",
    number = "5",
    pages = "1111-1118",
    publisher = "Wiley",
    issn = "0020-7136",
    doi = "10.1002/ijc.30528",
    keywords = "prospective; lymphoma; non-Hodgkin lymphoma; plasma; IGF-I; EPIC cohort;
nested case-control",
    abstract = "Insulin-like growth factor (IGF)-I has cancer promoting activities.
However, the hypothesis that circulating IGF-I concentration is related
to risk of lymphoma overall or its subtypes has not been examined
prospectively. IGF-I concentration was measured in pre-diagnostic plasma
samples from a nested case-control study of 1,072 cases of lymphoid
malignancies and 1,072 individually matched controls from the European
Prospective Investigation into Cancer and Nutrition. Odds ratios (ORs)
and confidence intervals (CIs) for lymphoma were calculated using
conditional logistic regression. IGF-I concentration was not associated
with overall lymphoma risk (multivariable-adjusted OR for highest versus
lowest third = 0.77 [95% CI = 0.57-1.03], p(trend) = 0.06). There was
no statistical evidence of heterogeneity in this association with IGF-I
by sex, age at blood collection, time between blood collection and
diagnosis, age at diagnosis, or body mass index (pheterogeneity for all
>= 0.05). There were no associations between IGF-I concentration and
risk for specific BCL subtypes, T-cell lymphoma or Hodgkin lymphoma,
although number of cases were small. In this European population, IGF-I
concentration was not associated with risk of overall lymphoma. This
study provides the first prospective evidence on circulating IGF-I
concentrations and risk of lymphoma. Further
What’s new?
Insulin-like growth factor I does not appear to influence lymphoma risk,
according to new results. IGF-I can promote some cancers, but there
hasn’t been a prospective epidemiological study examining the link
between IGF-I concentration and lymphoma risk. To uncover a link, these
authors arranged a NESTED case-control study with participants from the
European Prospective Investigation into Cancer and Nutrition (EPIC).
They tested for IGF-I in pre-diagnosis samples and found no association
between the factor and overall lymphoma risk, nor with any subtype,
although the number of cases was small for each subtype, and further
studies are necessary."
}