@article{3174981,
    title = "Identification of 12 new susceptibility loci for different histotypes of
epithelial ovarian cancer",
    author = "Phelan, Catherine M. and Kuchenbaecker, Karoline B. and Tyrer, Jonathan and P. and Kar, Siddhartha P. and Lawrenson, Kate and Winham, Stacey J. and and Dennis, Joe and Pirie, Ailith and Riggan, Marjorie J. and Chornokur, and Ganna and Earp, Madalene A. and Lyra, Jr., Paulo C. and Lee, Janet M. and and Coetzee, Simon and Beesley, Jonathan and McGuffog, Lesley and Soucy, and Penny and Dicks, Ed and Lee, Andrew and Barrowdale, Daniel and and Lecarpentier, Julie and Leslie, Goska and Aalfs, Cora M. and Aben, Katja and K. H. and Adams, Marcia and Adlard, Julian and Andrulis, Irene L. and and Anton-Culver, Hoda and Antonenkova, Natalia and Aravantinos, Gerasimos and and Arnold, Norbert and Arun, Banu K. and Arver, Brita and Azzollini, and Jacopo and Balmana, Judith and Banerjee, Susana N. and Barjhoux, Laure and and Barkardottir, Rosa B. and Bean, Yukie and Beckmann, Matthias W. and and Beeghly-Fadiel, Alicia and Benitez, Javier and Bermisheva, Marina and and Bernardini, Marcus Q. and Birrer, Michael J. and Bjorge, Line and Black, and Amanda and Blankstein, Kenneth and Blok, Marinus J. and Bodelon, Clara and and Bogdanova, Natalia and Bojesen, Anders and Bonanni, Bernardo and and Borg, Ake and Bradbury, Angela R. and Brenton, James D. and Brewer, and Carole and Brinton, Louise and Broberg, Per and Brooks-Wilson, Angela and and Bruinsma, Fiona and Brunet, Joan and Buecher, Bruno and Butzow, Ralf and and Buys, Saundra S. and Caldes, Trinidad and Caligo, Maria A. and and Campbell, Ian and Cannioto, Rikki and Carney, Michael E. and Cescon, and Terence and Chan, Salina B. and Chang-Claude, Jenny and Chanock, Stephen and and Chen, Xiao Qing and Chiew, Yoke-Eng and Chiquette, Jocelyne and and Chung, Wendy K. and Claes, Kathleen B. M. and Conner, Thomas and Cook, and Linda S. and Cook, Jackie and Cramer, Daniel W. and Cunningham, Julie M. and and D'Aloisio, Aimee A. and Daly, Mary B. and Damiola, Francesca and and Damirovna, Sakaeva Dina and Dansonka-Mieszkowska, Agnieszka and Dao, and Fanny and Davidson, Rosemarie and DeFazio, Anna and Delnatte, Capucine and and Doheny, Kimberly F. and Diez, Orland and Ding, Yuan Chun and and Doherty, Jennifer Anne and Domchek, Susan M. and Dorfling, Cecilia M. and and Dork, Thilo and Dossus, Laure and Duran, Mercedes and Durst, and Matthias and Dworniczak, Bernd and Eccles, Diana and Edwards, Todd and and Eeles, Ros and Eilber, Ursula and Ejlertsen, Bent and Ekici, Arif B. and and Ellis, Steve and Elvira, Mingajeva and Eng, Kevin H. and Engel, and Christoph and Evans, D. Gareth and Fasching, Peter A. and Ferguson, and Sarah and Ferrer, Sandra Fert and Flanagan, James M. and Fogarty, and Zachary C. and Fortner, Renee T. and Fostira, Florentia and Foulkes, and William D. and Fountzilas, George and Fridley, Brooke L. and Friebel, and Tara M. and Friedman, Eitan and Frost, Debra and Ganz, Patricia A. and and Garber, Judy and Garcia, Maria J. and Garcia-Barberan, Vanesa and and Gehrig, Andrea and Gentry-Maharaj, Aleksandra and Gerdes, Anne-Marie and and Giles, Graham G. and Glasspool, Rosalind and Glendon, Gord and Godwin, and Andrew K. and Goldgar, David E. and Goranova, Teodora and Gore, Martin and and Greene, Mark H. and Gronwald, Jacek and Gruber, Stephen and Hahnen, and Eric and Haiman, Christopher A. and Hakansson, Niclas and Hamann, Ute and and Hansen, Thomas V. O. and Harrington, Patricia A. and Harris, Holly and R. and Hauke, Jan and Hein, Alexander and Henderson, Alex and and Hildebrandt, Michelle A. T. and Hillemanns, Peter and Hodgson, Shirley and and Hogdall, Claus K. and Hogdall, Estrid and Hogervorst, Frans B. L. and and Holland, Helene and Hooning, Maartje J. and Hosking, Karen and and Huang, Ruea-Yea and Hulick, Peter J. and Hung, Jillian and Hunter, David and J. and Huntsman, David G. and Huzarski, Tomasz and Imyanitov, Evgeny N. and and Isaacs, Claudine and Iversen, Edwin S. and Izatt, Louise and and Izquierdo, Angel and Jakubowska, Anna and James, Paul and Janavicius, and Ramunas and Jernetz, Mats and Jensen, Allan and Jensen, Uffe Birk and and John, Esther M. and Johnatty, Sharon and Jones, Michael E. and Kannisto, and Paivi and Karlan, Beth Y. and Karnezis, Anthony and Kast, Karin and and Kennedy, Catherine J. and Khusnutdinova, Elza and Kiemeney, Lambertus A. and and Kiiski, Johanna I. and Kim, Sung-Won and Kjaer, Susanne K. and and Kobel, Martin and Kopperud, Reidun K. and Kruse, Torben A. and and Kupryjanczyk, Jolanta and Kwong, Ava and Laitman, Yael and Lambrechts, and Diether and Larranaga, Nerea and Larson, Melissa C. and Lazaro, Conxi and and Le, Nhu D. and Le Marchand, Loic and Lee, Jong Won and Lele, and Shashikant B. and Leminen, Arto and Leroux, Dominique and Lester, Jenny and and Lesueur, Fabienne and Levine, Douglas A. and Liang, Dong and and Liebrich, Clemens and Lilyquist, Jenna and Lipworth, Loren and and Lissowska, Jolanta and Lu, Karen H. and Lubinski, Jan and Luccarini, and Craig and Lundvall, Lene and Mai, Phuong L. and Mendoza-Fandino, Gustavo and and Manoukian, Siranoush and Massuger, Leon F. A. G. and May, Taymaa and and Mazoyer, Sylvie and McAlpine, Jessica N. and McGuire, Valerie and and McLaughlin, John R. and McNeish, Iain and Meijers-Heijboer, Hanne and and Meindl, Alfons and Menon, Usha and Mensenkamp, Arjen R. and Merritt, and Melissa A. and Milne, Roger L. and Mitchell, Gillian and Modugno, and Francesmary and Moes-Sosnowska, Joanna and Moffitt, Melissa and and Montagna, Marco and Moysich, Kirsten B. and Mulligan, Anna Marie and and Musinsky, Jacob and Nathanson, Katherine L. and Nedergaard, Lotte and and Ness, Roberta B. and Neuhausen, Susan L. and Nevanlinna, Heli and and Niederacher, Dieter and Nussbaum, Robert L. and Odunsi, Kunle and Olah, and Edith and Olopade, Olufunmilayo I. and Olsson, Hakan and Olswold, Curtis and and O'Malley, David M. and Ong, Kai-ren and Onland-Moret, N. Charlotte and and Orr, Nicholas and Orsulic, Sandra and Osorio, Ana and Palli, and Domenico and Papi, Laura and Park-Simon, Tjoung-Won and Paul, James and and Pearce, Celeste L. and Pedersen, Inge Sokilde and Peeters, Petra H. M. and and Peissel, Bernard and Peixoto, Ana and Pejovic, Tanja and Pelttari, and Liisa M. and Permuth, Jennifer B. and Peterlongo, Paolo and Pezzani, and Lidia and Pfeiler, Georg and Phillips, Kelly-Anne and Piedmonte, Marion and and Pike, Malcolm C. and Piskorz, Anna M. and Poblete, Samantha R. and and Pocza, Timea and Poole, Elizabeth M. and Poppe, Bruce and Porteous, Mary and E. and Prieur, Fabienne and Prokofyeva, Darya and Pugh, Elizabeth and and Pujana, Miquel Angel and Pujol, Pascal and Radice, Paolo and Rantala, and Johanna and Rappaport-Fuerhauser, Christine and Rennert, Gad and Rhiem, and Kerstin and Rice, Patricia and Richardson, Andrea and Robson, Mark and and Rodriguez, Gustavo C. and Rodriguez-Antona, Cristina and Romm, Jane and and Rookus, Matti A. and Rossing, Mary Anne and Rothstein, Joseph H. and and Rudolph, Anja and Runnebaum, Ingo B. and Salvesen, Helga B. and Sandler, and Dale P. and Schoemaker, Minouk J. and Senter, Leigha and Setiawan, V. and Wendy and Severi, Gianluca and Sharma, Priyanka and Shelford, Tameka and and Siddiqui, Nadeem and Side, Lucy E. and Sieh, Weiva and Singer, Christian and F. and Sobol, Hagay and Song, Honglin and Southey, Melissa C. and and Spurdle, Amanda B. and Stadler, Zsofia and Steinemann, Doris and and Stoppa-Lyonnet, Dominique and Sucheston-Campbell, Lara E. and and Sukiennicki, Grzegorz and Sutphen, Rebecca and Sutter, Christian and and Swerdlow, Anthony J. and Szabo, Csilla I. and Szafron, Lukasz and Tan, and Yen Y. and Taylor, Jack A. and Tea, Muy-Kheng and Teixeira, Manuel R. and and Teo, Soo-Hwang and Terry, Kathryn L. and Thompson, Pamela J. and and Thomsen, Liv Cecilie Vestrheim and Thull, Darcy L. and Tihomirova, Laima and and Tinker, Anna V. and Tischkowitz, Marc and Tognazzo, Silvia and and Toland, Amanda Ewart and Tone, Alicia and Trabert, Britton and Travis, and Ruth C. and Trichopoulou, Antonia and Tung, Nadine and Tworoger, Shelley and S. and Van Altena, Anne M. and Van den Berg, David and van der Hout, and Annemarie H. and van der Luijt, Rob B. and Van Heetvelde, Mattias and and Van Nieuwenhuysen, Els and Van Rensburg, Elizabeth J. and and Vanderstichele, Adriaan and Varon-Mateeva, Raymonda and Vega, Ana and and Edwards, Digna Velez and Vergote, Ignace and Vierkant, Robert A. and and Vijai, Joseph and Vratimos, Athanassios and Walker, Lisa and Walsh, and Christine and Wand, Dorothea and Wang-Gohrke, Shan and Wappenschmidt, and Barbara and Webb, Penelope M. and Weinberg, Clarice R. and Weitzel, and Jeffrey N. and Wentzensen, Nicolas and Whittemore, Alice S. and Wijnen, and Juul T. and Wilkens, Lynne R. and Wolk, Alicja and Woo, Michelle and Wu, and Xifeng and Wu, Anna H. and Yang, Hannah and Yannoukakos, Drakoulis and and Ziogas, Argyrios and Zorn, Kristin K. and Narod, Steven A. and Easton, and Douglas F. and Amos, Christopher I. and Schildkraut, Joellen M. and and Ramus, Susan J. and Ottini, Laura and Goodman, Marc T. and Park-, Sue K. and and Kelemen, Linda E. and Risch, Harvey A. and Thomassen, Mads and and Offit, Kenneth and Simard, Jacques and Schmutzler, Rita Katharina and and Hazelett, Dennis and Monteiro, Alvaro N. and Couch, Fergus J. and and Berchuck, Andrew and Chenevix-Trench, Georgia and Goode, Ellen L. and and Sellers, Thomas A. and Gayther, Simon A. and Antoniou, Antonis C. and and Pharoah, Paul D. P. and AOCS Study Grp and EMEMBRACE Study and GEMO and Study Collaborators and HEBON Study and KConFab Investigators and OPAL and Study Grp",
    journal = "Nature Genetics",
    year = "2017",
    volume = "49",
    number = "5",
    pages = "680-691",
    publisher = "Nature Publishing Group",
    issn = "1061-4036, 1546-1718",
    doi = "10.1038/ng.3826",
    abstract = "To identify common alleles associated with different histotypes of
epithelial ovarian cancer (EOC), we pooled data from multiple
genome-wide genotyping projects totaling 25,509 EOC cases and 40,941
controls. We identified nine new susceptibility loci for different EOC
histotypes: six for serous EOC histotypes (3q28, 4q32.3, 8q21.11,
10q24.33, 18q11.2 and 22q12.1), two for mucinous EOC (3q22.3 and 9q31.1)
and one for endometrioid EOC (5q12.3). We then performed meta-analysis
on the results for high-grade serous ovarian cancer with the results
from analysis of 31,448 BRCA1 and BRCA2 mutation carriers, including
3,887 mutation carriers with EOC. This identified three additional
susceptibility loci at 2q13, 8q24.1 and 12q24.31. Integrated analyses of
genes and regulatory biofeatures at each locus predicted candidate
susceptibility genes, including OBFC1, a new candidate susceptibility
gene for low-grade and borderline serous EOC."
}