@article{3175271,
    title = "Measured Adiposity in Relation to Head and Neck Cancer Risk in the
European Prospective Investigation into Cancer and Nutrition",
    author = "Ward, Heather A. and Wark, Petra A. and Muller, David C. and Steffen, and Annika and Johansson, Mattias and Norat, Teresa and Gunter, Marc J. and and Overvad, Kim and Dahm, Christina C. and Halkjaer, Jytte and Tojonneland, and Anne and Boutron-Ruault, Marie-Christine and Fagherazzi, Guy and and Mesrine, Sylvie and Brennan, Paul and Freisling, Heinz and Li, Kuanrong and and Kaaks, Rudolf and Trichopoulou, Antonia and Lagiou, Pagona and and Panico, Salavatore and Grioni, Sara and Tumino, Rosario and Vineis, and Paolo and Palli, Domenico and Peeters, Petra H. M. and and Bueno-de-Mesquita, H. Bas. and Weiderpass, Elisabete and Agudo, Antonio and and Ramon Quiros, Jose and Larranaga, Nerea and Ardanaz, Eva and Maria and Huerta, Jose and Sanchez, Maria-Jose and Laurell, Goran and Johansson, and Ingegerd and Westin, Ulla and Wallstrom, Peter and Bradbury, Kathryn E. and and Wareham, Nicholas J. and Khaw, Kay-Tee and Pearson, Clare and and Boeing, Heiner and Riboli, Elio",
    journal = "Cancer Epidemiology, Biomarkers & Prevention",
    year = "2017",
    volume = "26",
    number = "6",
    pages = "895-904",
    publisher = "AMER ASSOC CANCER RESEARCH",
    issn = "1055-9965, 1538-7755",
    doi = "10.1158/1055-9965.EPI-16-0886",
    abstract = "Background: Emerging evidence from cohort studies indicates that
adiposity is associated with greater incidence of head and neck cancer.
However, most studies have used self-reported anthropometry which is
prone to error.
Methods: Among 363,094 participants in the European Prospective
Investigation into Cancer and Nutrition study (EPIC) with measured
anthropometry, there were 837 incident cases of head and neck cancer.
Head and neck cancer risk was examined in relation to body mass index
(BMI) [lean: <22.5 kg/m(2), normal weight (reference): 22.5-24.9
kg/m(2), overweight 25-29.9 kg/m(2), obese: >= 30 kg/m(2)], waist
circumference (WC), hip circumference (HC), and waist-to-hip ratio (WHR)
using Cox proportional hazards models.
Results: Among men, a BMI <22.5 kg/m(2) was associated with higher head
and neck cancer risk [HR 1.62; 95% confidence interval (CI),
1.23-2.12)]; BMI was not associated with head and neck cancer among
women. WC and WHR were associated with greater risk of head and neck
cancer among women (WC per 5 cm: HR, 1.08; 95% CI, 1.02-1.15; WHR per
0.1 unit: HR, 1.64; 95% CI, 1.38-1.93). After stratification by smoking
status, the association for WHR was present only among smokers
(P-interaction = 0.004). Among men, WC and WHR were associated with head
and neck cancer only upon additional adjustment for BMI (WC per 5 cm: HR
1.16; 95% CI, 1.07-1.26; WHR per 0.1 unit: HR, 1.42; 95% CI,
1.21-1.65).
Conclusions: Central adiposity, particularly among women, may have a
stronger association with head and neck cancer risk than previously
estimated."
}