@article{3179368,
    title = "Antioxidant treatment in peripheral artery disease: the rationale is
there, but what about clinical results?",
    author = "Giannopoulos, Georgios and Angelidis, Christos and Vogiatzi, Georgia and and Cleman, Michael W. and Deftereos, Spyridon",
    journal = "Current Opinion in Pharmacology",
    year = "2018",
    volume = "39",
    pages = "53-59",
    publisher = "Elsevier Sci Ltd, Exeter, United Kingdom",
    issn = "1471-4892",
    doi = "10.1016/j.coph.2018.01.008",
    abstract = "Peripheral arterial disease is a major cause of morbidity and disability
and has been consistently associated with an adverse overall prognosis.
Oxidative stress has been linked to vascular disease, with several
suggested pathogenetic mechanisms, leading to various insults of the
arterial wall and, ultimately, to atherothrombotic disease. Considering
that the pathophysiological background is quite compelling, attenuation
of oxidative processes by means of various substances with antioxidant
properties has been conceived as a promising therapeutic target.
However, clinical results have been mostly disappointing and
`antioxidant' therapies are still far from being integrated into
treatment algorithms for vascular disease."
}