@article{3182151,
    title = "Non-Hodgkin lymphoma risk in adults living with HIV across five
continents The AIDS-defining Cancer Project Working Group of leDEA and
COHERE in EuroCoord",
    author = "Rohner, Eliane and Butikofer, Lukas and Schmidlin, Kurt and Sengayi, and Mazvita and Maskew, Mhairi and Giddy, Janet and Moore, Richard D. and and Goedert, James J. and Gill, M. John and Silverberg, Michael J. and and Patel, Pragna and Castilho, Jessica and Hoy, Jennifer and Sohn, Annette and and Bani-Sadr, Firouze and Taylor, Ninon and Paparizos, Vassilios and Le and Moing, Vincent and Bonnet, Fabrice and Verbon, Annelies and Vehreschild, and Jorg Janne and Post, Frank A. and Sabin, Caroline and Mocroft, Amanda and and Dronda, Fernando and Obel, Niels and Grabar, Sophie and Spagnuolo, and Vincenzo and Antinori, Andrea and Quiros-Rol-dan, Eugenia and Mussini, and Cristina and Miro, Jose M. and Meyer, Laurence and Hasse, Barbara and and Konopnicki, Deborah and Roca, Bernardino and Boue, Francois and Barger, and Diana and Raben, Dorthe and Clifford, Gary M. and Franceschi, Silvia and and Brockmeyer, Norbert and Egger, Matthias and Bohlius, Julia and and AIDS-Defining Cancer Project Work",
    journal = "Ελληνικά Αρχεία AIDS=:  Hellenic Archives of AIDS",
    year = "2018",
    volume = "32",
    number = "18",
    pages = "2777-2786",
    publisher = "Lippincott, Williams & Wilkins",
    issn = "11058900",
    doi = "10.1097/QAD.0000000000002003",
    keywords = "antiretroviral therapy; cohort study; HIV; incidence rates; non-Hodgkin
lymphoma",
    abstract = "Objective: To compare non-I lodgkin lymphoma (NHL) incidence rates in
adults who started antiretroviral therapy (ART) across the Asia-Pacific,
South Africa, Europe, Latin, and North America.
Methods: We included cohort data of adults living with HIV who started
ART after 1995 within the framework of the International epidemiology
Databases to Evaluate AIDS (leDEA) and (he Collaboration of
Observational HIV Epidemiological Research in Europe (COHERE). We used
flexible parametric survival models to compare regional NHL rates at 2
years after ART start and to identify risk factors for NHL.
Results: We included 210898 adults with 1.1 million person-years (pys)
of follow-up and 1552 incident NHL cases (raw overall incidence rate
142/100000 pys). After adjusting for age at ART start, first-line ART
regimen, calendar period of ART start, and especially current CD4(+)
cell count, NHL rates were similar across regions for most population
groups. However, South African women remained at increased risk of
developing NHL compared with their European counterparts [adjusted
hazard ratio [aHR] 1.79, 95% CI 1.19-2.701. In Europe, Latin, and
North America, NHL risk was highest in MSM (aHR 1.30, 95% CI
1.14-1.48), followed by heterosexual men (referent), and women (aHR
0.66, 95% CI 0.57-0.78).
Conclusion: The risk of developing NHL is higher in women in South
Africa than in Europe and higher in MSM compared with heterosexual men
and women. Reasons for these differences remain unclear. Early ART
access and regular patient monitoring to avert low CD4(+) cell counts
remain key for NHL prevention. copyright (C) 2018 WolLers Kluwer Health,
Inc. All rights reserved."
}