@inproceedings{3182807,
    title = "Topographic imaging of an absorbing object in a tissue-like scattering
medium using a single source-detector pair",
    author = "Mertiri, M. and Raptis, N. and Fragkos, M. A. and Roditi, E. and and Syvridis, D.",
    year = "2019",
    publisher = "SPIE - INT SOC OPTICAL ENGINEERING",
    booktitle = "SMART BIOMEDICAL AND PHYSIOLOGICAL SENSOR TECHNOLOGY XV",
    doi = "10.1117/12.2519004",
    keywords = "Diffuse optic topography; biomedical optical imaging; Monte Carlo
simulation",
    abstract = "Diffuse optical tomography is an emerging biomedical imaging technique,
due to its numerous advantages, such as low cost and non-ionizing
radiation. In this work, we have developed a very simple setup, which
included a single source - photodiode (SP) pair for scanning a sample of
water with diluted Intralipid, simulating a biological tissue. LEDs
emitting at 470, 525 and 624 nm, as well as a 650 nm Fabry Perot laser,
were used as light sources. Scattered light from the sample was detected
by the photodiode placed next to the LED. The SP distance could vary and
the phantom could be scanned by moving the SP pair in precise, small and
automated steps without any intervention during the measurements.
Therefore, we obtained measurements from multiple locations on the
sample, with just one SP pair. The presented experimental system
verified the feasibility of deploying extremely low cost devices for
detection and imaging absorbing objects of 1 cm height, placed inside a
scattering medium. Maximum depth detection was 2.5 cm. As expected, the
quality of the obtained images was degrading, as the object's depth or
the scanning step was increasing. Additionally, we developed Monte Carlo
simulations of the setup, which achieved good agreement with the
experimental results. We also conducted another set of simulations,
studying the depth sensitivity of a single static SP pair considering a
scattering medium similar to the experimental phantom with and without
object. We observed that the depth sensitivity increases as the source
wavelength increases from 450 nm to 650 nm."
}