@article{3182851,
    title = "Luteal phase progesterone and estradiol concentrations and their
relation to the outcome of IVF/ICSI cycles with controlled ovarian
stimulation",
    author = "Bakas, P. and Simopoulou, M. and Panagopoulos, P. and Salakos, N. and and Siristatidis, Ch",
    journal = "Clinical and Experimental Obstetrics & Gynecology",
    year = "2019",
    volume = "46",
    number = "5",
    pages = "727-730",
    publisher = "7847050 Canada Inc.",
    issn = "0390-6663",
    doi = "10.12891/ceog4741.2019",
    keywords = "Estradiol; Progesterone; Ganirelix; Controlled ovarian stimulation; COS;
IVF; ICSI",
    abstract = "Purpose of Investigation: To examine if the potential changes in
progesterone (P) and estradiol (E2) levels during the luteal phase can
predict the outcome in IVF/ICSI cycles. Material and Methods: A
prospective study of 282 patients with infertility undergoing IVF/ICSI
have been included. Serum E2 and P measurements at day of hCG triggering
and days 6 and 10 after embryo transfer in conception and non-conception
cycles. Results: The ROC curve in predicting clinical pregnancy was
calculated at 0.864 (95% CI: 0.841-0.92). A maximum reduction of <= 32
% demonstrated sensitivity of 84.3% and specificity of 80.4%. The
corresponding ROC curve for percentage change in P levels was 0.733 with
95% CI: 0.334-0.96. Conclusion: A maximum reduction of 32 % in E2
levels between days 6 and 10 after embryo transfer demonstrated a
predictive ability for clinical pregnancy after IVF/ICSI of 86.4% with
sensitivity 84.3% and specificity 80.4%."
}