@article{3183280,
    title = "Colorectal Neuroendocrine Neoplasms: Areas of Unmet Need",
    author = "Ramage, John K. and Valle, Juan W. and van Dijkum, Els J. M. Nieveen and and Sundin, Anders and Pascher, Andreas and Couvelard, Anne and Kloeppel, and Guenter and Bartsch, Detlef and Arnold, Rudolf and Baudin, Eric and and Bodei, Lisa and Borbath, Iva and Capdevila, Jaume and Caplin, Matyn and and Chen, Jie and Costa, Frederico and Couvelard, Anne and Cwikla, Jaroslaw and B. and Davies, Philippa and de Herder, Wouter W. and Falconi, Massimo and and Falkerby, Jenny and Fazio, Nicola and Ferone, Diego and Frilling, and Andrea and Garcia-Carbonero, Rocio and Glasberg, Simona and Gorbunova, and Vera and Grossman, Ashley and Hoersch, Dieter and Jensen, Robert and and Kaltsas, Gregory and Kloeppel, Guenter and Kingge, Ulrich Peter and and Kos-Kudla, Beata and Krejs, Guenter J. and Krenning, Eric and Kulke, and Matthew and Lamberts, Steven W. J. and Van Dijkum, Nieveen Els J. M. and and O'Connor, Juan Manuel and O'Toole, Dermot and Pape, Ulrich-Frank and and Partelli, Stefano and Pavel, Marianne Ellen and Peeters, Marc and and Ramage, John K. and Reed, Nicholas Simon and Rindi, Guido and Rinke, and Anja and Ruszniewski, Philippe and Sorbye, Halfdan and Sundin, Anders and and Scoazec, Jean-Yves and Taal, Babs G. and Janson, Tiensuu Eva and and Toumpanakis, Christos and Valle, Juan W. and Vullierme, Marie-Pierre and and Staffan, Welin and Wiedenmann, Bertman and ENETS 2016 Munich Advisory and Board",
    journal = "ISRN Neuroendocrinology",
    year = "2019",
    volume = "108",
    number = "1",
    pages = "45-53",
    publisher = "Karger",
    issn = "2090-7982",
    doi = "10.1159/000493767",
    keywords = "Carcinoid tumours; Gastroenteropancreatic neuroendocrine tumours;
Neuroendocrine tumour; Somatostatin receptor",
    abstract = "The subject of colorectal neuroendocrine neoplasms (NENs), subdivided
into well-differentiated NENs, termed neuroendocrine tumours (NETs;
grade (G) 1 and 2), and poorly differentiated NENs, termed
neuroendocrine carcinomas (NECs; G3) according to the 2010 World Health
Organisation (WHO) classification, has arguably not had as much
attention or study as NENs occurring in other sites. Colorectal NETs and
NECs are however easier to study than many others since they are usually
not difficult to remove and are increasingly detected because of
intensified colorectal cancer screening and surveillance programmes.
Colorectal NETs and NECs show site-specific heterogeneity with variable
behaviour and different therapeutic options; these various aspects
provide unique challenges. Because of bowel cancer screening programmes,
colorectal NENs, like conventional adenocarcinomas, may be diagnosed at
a stage that is associated with improved survival. In this article we
intend to describe and define areas of unmet needs relating to the
epidemiology, classification, pathology, diagnosis and therapy of
colorectal NETs (including NETs G3), colorectal NECs, and finally, mixed
adeno-neuroendocrine carcinomas (MANECs) by reviewing and discussing the
relevant literature."
}