@article{3183798,
    title = "The proportion of different BCR-ABL1 transcript types in chronic myeloid
leukemia. An international overview",
    author = "Baccarani, Michele and Castagnetti, Fausto and Gugliotta, Gabriele and and Rosti, Gianantonio and Soverini, Simona and Albeer, Ali and Pfirrmann, and Markus and Bekadja, Mohamed-Amine and Entasoltan, Badra and Nachi, and Mourad and Elghandour, Ashraf and El Sorady, Manal and Abdelfattah, and Raafat and El Nahass, Yasser and Samra, Mohamed and Azzazi, Mohammed and and Elsobki, Ezat and Moussa, Mohamed and Fahmy, Omar and Mattar, Mervat and and Shehata, Samir Eid and Azmy, Emad and Bolarinwa, Rahman A. and Eid, and Samir and Khelif, Abderrhaim and Hached, Farhat and Menif, Samia and and Rahman, Hafizur and Huang, Xiaojun and Jiang, Qian and Ye, Yuanxin and and Zhu, Huanling and Chen, Suning and Varma, Neelam and Ganesan, Prasanth and and Gundeti, Sadashivudu and Malhotra, Hemant and Radhakrishnan, Vivek and S. and Kumar, Lalit and Sharawat, Surender Kumar and Seth, Tulika and and Ausekar, B. V. and Balasubramanian, Poonkuzhali and Poopak, Behzad and and Inokuchi, Koiti and Kim, Dong-Wook and Al Kindi, Salam and Mirasol, and Angelina and Qari, Mohammed and Goh, Yeow Tee and Shih, Lee-Yung and and Branford, Susan and Lion, Thomas and Valent, Peter and Burgstaller, and Sonja and Thaler, Joseph and Labar, Boris and Zadro, Renata and Mayer, and Jiri and Zackova, Daniela and Faber, Edgar and Pallisgaard, Niels and and Xavier-Mahon, Francois and Lippert, Eric and Cayuela, Jean Michel and and Rea, Delphine and Millot, Frederic and Suttorp, Meinolf and Hochhaus, and Andreas and Niederwieser, Dietger and Saussele, Susanne and Haferlach, and Torsten and Jeromine, Sabine and Panayiotidis, Panayiotis and Conneally, and Eibhlin and Langabeer, Steve and Nagler, Arnon and Rupoli, Serena and and Santoro, Nicola and Albano, Francesco and Castagnetti, Fausto and and Ottaviani, Emanuela and Rambaldi, Alessandro and Stagno, Fabio and and Molica, Stefano and Biagiotti, Caterina and Scappini, Barbara and and Lemoli, Roberto and Iurlo, Alessandra and Pungolino, Ester and Menna, and Giuseppe and Pane, Fabrizio and Gottardi, Enrico and Rege-Cambrin, and Giovanna and Binotto, Gianni and Putti, Maria Caterina and Falzetti, and Franca and Visani, Giuseppe and Galimberti, Sara and Musto, Pellegrino and and Abruzzese, Elisabetta and Breccia, Massimo and Giona, Fiorina and and Chiusolo, Patrizia and Sica, Simona and Fava, Carmen and Ferrero, Dario and and Tiribelli, Mario and Bonifacio, Massimiliano and Griskevicius, and Laimonas and Musteata, Vasile and Janssen, Jeroen and Prejzner, Witold and and Sacha, Tomasz and Waclaw, Joanna and Almeida, Antonio Medina and and Kulikov, Sergei and Turkina, Anna and Bogdanovic, Andrija and Zupan, and Irena and Marce, Silvia and Cervantes, Francisco and Steegmann, Juan and Luis and Kotlyarchuk, Konstyantyn and Milner, Benedict J. and Rose, and Susan and Clench, Tim and Waits, Paula and Austin, Steve and Wickham, and Caroline and Clark, Richard and Apperley, Jane and Claudiani, Simone and and Foroni, Letizia and Szydlo, Richard and Burt, Emma and Bescoby, Ruth and and Cork, Leanne and O'Brien, Stephen and Green, Bethaney and Hawtree, Sarah and and Watson, Mark and Bengio, Raquel Maria and Larripa, Irene and and Pavlovsky, Carolina and Moiraghi, Beatriz and Requiao de Pinna, and Cristiane Almeida and Romani Magalhaes, Gustavo Henrique and Pagnano, and Katia and Funke, Vaneuza and Tavares, Renato Sampaio and Prado, Adriana and and Azevedo, Alita Andrade and Fogliatto, Laura and Bonecker, Simone and and Centrone, Renato and Moellman, Artur and Conchon, Monika and Centurion, and Maria Elida and Prado, Ana-Ines and Lopez, J. L. and Petruzziello, Fara and and Bendit, Israel and Int BCR-ABL Study Grp",
    journal = "Leukemia Research",
    year = "2019",
    volume = "33",
    number = "5",
    pages = "1173-1183",
    publisher = "Nature Publishing Group",
    issn = "0145-2126",
    doi = "10.1038/s41375-018-0341-4",
    abstract = "There are different BCR-ABL1 fusion genes that are translated into
proteins that are different from each other, yet all leukemogenic,
causing chronic myeloid leukemia (CML) or acute lymphoblastic leukemia.
Their frequency has never been systematically investigated. In a series
of 45503 newly diagnosed CML patients reported from 45 countries, it was
found that the proportion of e13a2 (also known as b2a2) and of e14a2
(also known as b3a2), including the cases co-expressing e14a2 and el
3a2, was 37.9% and 62.1%, respectively. The proportion of these two
transcripts was correlated with gender, e13a2 being more frequent in
males (39.2%) than in females (36.2%), was correlated with age,
decreasing from 39.6% in children and adolescents down to 31.6% in
patients >= 80 years old, and was not constant worldwide. Other, rare
transcripts were reported in 666/34561 patients (1.93%). The proportion
of rare transcripts was associated with gender (2.27% in females and
1.69% in males) and with age (from 1.79% in children and adolescents
up to 3.84% in patients >= 80 years old). These data show that the
differences in proportion are not by chance. This is important, as the
transcript type is a variable that is suspected to be of prognostic
importance for response to treatment, outcome of treatment, and rate of
treatment-free remission."
}