@article{3184305,
    title = "A worldwide perspective of sepsis epidemiology and survival according to
age: Observational data from the ICON audit",
    author = "Kotfis, Katarzyna and Wittebole, Xavier and Jaschinski, Ulrich and and Sole-Violan, Jordi and Kashyap, Rahul and Leone, Marc and Nanchal, Rahul and and Fontes, Luis E. and Sakr, Yasser and Vincent, Jean-Louis and Tomas, and E. and Bibonge, E. 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Valcoreanu and Slavcovici, A. and Bagin, V and and Belsky, D. and Palyutin, S. and Shlyapnikov, S. and Bikkulova, D. and and Gritsan, A. and Natalia, G. and Makarenko, E. and Kokhno, V and Tolkach, and A. and Kokarev, E. and Belotserkovskiy, B. and Zolotukhin, K. and and Kulabukhov, V and Soskic, L. and Palibrk, I and Jankovic, R. and and Jovanovic, B. and Pandurovic, M. and Bumbasirevic, V and Uljarevic, B. and and Surbatovic, M. and Ladjevic, N. and Slobodianiuk, G. and Sobona, V and and Cikova, A. and Gebhardtova, A. and Jun, C. and Yunbo, S. and Dong, and U. and Feng, S. and Duan, M. and Xu, Y. and Xue, X. and Gao, T. and and Xing, X. and Zhao, X. and Li, C. and Gengxihua, G. and Tan, H. and Xu, and J. and Jiang, L. and Tiehe, Q. and Bingyu, Q. and Shi, Q. and Lv, Z. and and Zhang, L. and Jingtao, L. and Zhen, Z. and Wang, Z. and Wang, T. and and Yuhong, L. and Zhai, Q. and Chen, Y. and Wang, C. and Jiang, W. and and Ruilan, W. and Chen, Y. and Xiaobo, H. and Ge, H. and Yan, T. and Yuhui, and C. and Zhang, J. and Jian-Hong, F. and Zhu, H. and Huo, F. and Wang, Y. and and Li, C. and Zhuang, M. and Ma, Z. and Sun, J. and Liuqingyue, L. and and Yang, M. and Meng, J. and Ma, S. and Kang, Y. and Yu, L. and Peng, Q. and and Wei, Y. and Zhang, W. and Sun, R. and Yeung, A. and Wan, W. and Sin, and K. and Lee, K. and Wijanti, M. and Widodo, U. and Samsirun, H. and and Sugiman, T. and Wisudarti, C. and Maskoen, T. and Hata, N. and Kobe, Y. and and Nishida, O. and Miyazaki, D. and Nunomiya, S. and Uchino, S. and and Kitamura, N. and Yamashita, K. and Hashimoto, S. and Fukushima, H. and and Adib, N. Nik and Tai, L. and Tony, B. and Bigornia, R. and Palo, J. and and Chatterjee, S. and Tan, B. and Kong, A. and Goh, S. and Lee, C. and and Pothirat, C. and Khwannimit, B. and Theerawit, P. and Pornsuriyasak, P. and and Piriyapatsom, A. and Mukhtar, A. and Dsicu and Hamdy, A. Nabil and and Hosny, H. and Ashraf, A. and Mokhtari, M. and Nowruzinia, S. and Lotfi, and A. and Zand, F. and Nikandish, R. and Moghaddam, O. Moradi and Cohen, J. and and Sold, O. and Sfeir, T. and Hasan, A. and Abugaber, D. and Ahmad, H. and and Tantawy, T. and Baharoom, S. and Algethamy, H. and Amr, A. and and Almekhlafi, G. and Coskun, R. and Sungur, M. and Cosar, A. and and Gucyetmez, B. and Demirkiran, O. and Senturk, E. and Ulusoy, H. and and Atalan, H. and Serin, S. and Kati, I and Alnassrawi, Z. and Almemari, A. and and Krishnareddy, K. and Kashef, S. and Alsabbah, A. and Poirier, G. and and Marshall, J. and Herridge, M. and Herridge, M. and Fernandez-Medero, R. and and Fulda, G. and Banschbach, S. and Quintero, J. and Schroeder, E. and and Sicoutris, C. and Gueret, R. and Kashyap, R. and Bauer, P. and Nanchal, and R. and Wunderink, R. and Jimenez, E. and Ryan, A. and Prince, D. and and Edington, J. and Van Haren, F. and Bersten, A. and Hawkins, D. 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Kerin and and Osojnik, I and Tomic, V and Sinkovic, A. and Gonzalez, J. and Zavala, E. and and Perez Valenzuela, A. and Marina, L. and Vidal-Cortes, P. and Posada, and I and Ignacio Martin-Loeches, A. and Munoz Guillen, N. and Palomar, M. and and Sole-Violan, U. and Torres, A. and Gonzalez Gallego, M. and Aguilar, and G. and Montoiro Allue, R. and Argueso, M. and Parejo, M. and Palomo and Navarro, M. and Jose, A. and Nin, N. and Alvarez Lerma, F. and Martinez, and O. and Tenza Lozano, E. and Arenal Lopez, S. and Perez Granda, M. and and Moreno, S. and Llubia, C. and De la Fuente Martos, C. and and Gonzalez-Arenas, P. and Llamas Fernandez, N. and Gil Rueda, B. and and Estruch Pons, I and Cruza, N. and Maroto, F. and Estella, A. and Ferrer, and A. and Iglesias Fraile, L. and Quindos, B. and Quintano, A. and Tebar, and M. and Cardinal, I and Reyes, A. and Rodriguez, A. and Abella, A. and and Garcia Del Valle, S. and Yus, S. and Maseda, E. and Berezo, U. and and Tejero Pedregosa, A. and Laplaza, C. and Ferrer, R. and Rico-Feijoo, U. and and Rodriguez, M. and Monedero, P. and Eriksson, K. and Lind, D. and and Chabanel, D. and Zender, H. and Heer, K. and Frankenberger, B. and and Jakob, S. and Mathew, S. and Downes, R. and Groba, C. Barrera and and Johnston, A. and Meacher, R. and Keays, R. and Haji-Michael, P. and and Tyler, C. and Ferguson, A. and Jones, S. and Tyl, D. and Ball, A. and and Vogel, U. and Booth, M. and Downie, P. and Watters, M. and Brett, S. and and Garfield, M. and Everett, L. and Heenen, S. and Dhir, S. and Beardow, Z. and and Mostert, M. and Brosnan, S. and Pinto, N. and Harris, S. and and Summors, A. and Andrew, N. and Rose, A. and Appelboam, R. and Davies, O. and and Vickers, E. and Agarwal, B. and Szakmany, T. and Wimbush, S. and and Welters, I and Pearse, R. and Hollands, R. and Kirk-Bayley, U. and and Fletcher, N. and Bray, B. and Brealey, D. and ICON Investigators",
    journal = "Journal of Critical Care",
    year = "2019",
    volume = "51",
    pages = "122-132",
    publisher = "W B SAUNDERS CO-ELSEVIER INC",
    issn = "0883-9441",
    doi = "10.1016/j.jcrc.2019.02.015",
    keywords = "Mortality; Outcome; ICU",
    abstract = "Purpose: To investigate age-related differences in outcomes of
critically ill patients with sepsis around the world.
Methods: We performed a secondary analysis of data from the prospective
ICON audit, in which all adult ( >16 years ) patients admitted to
participating ICUs between May 8 and 18, 2012, were included, except
admissions for routine postoperative observation. For this sub-analysis,
the 10,012 patients with completed age data were included. They were
divided into five age groups - <= 50, 51-60, 61-70, 71-80, >80 years.
Sepsis was defined as infection plus at least one organ failure.
Results: A total of 2963 patients had sepsis, with similar proportions
across the age groups (<= 50 = 25.2%: 51-60 = 30.3%; 61-70 = 32.8%;
71-80 = 30.7%; >80 = 30.9%). Hospital mortality increased with age and
in patients >80 years was almost twice that of patients <= 50 years
(493% vs 25.2%, p < .05). The maximum rate of increase in mortality
was about 0.75% per year, occurring between the ages of 71 and 77
years. In multilevel analysis, age > 70 years was independently
associated with increased risk of dying.
Conclusions: The odds for death in ICU patients with sepsis increased
with age with the maximal rate of increase occurring between the ages of
71 and 77 years. (C) 2019 Elsevier Inc. All rights reserved."
}