@article{3187473,
    title = "The Beneficial Effect of the Mobile Application Euglyca in Children and
Adolescents with Type 1 Diabetes Mellitus: A Randomized Controlled Trial",
    author = "Chatzakis, Christos and Floros, Dimitrios and Papagianni, Maria and and Tsiroukidou, Kyriaki and Kosta, Konstantina and Vamvakis, Anastasios and and Koletsos, Nikolaos and Hatziagorou, Elpida and Tsanakas, Ioannis and and Mastorakos, George",
    journal = "Diabetes Technology & Therapeutics",
    year = "2019",
    volume = "21",
    number = "11",
    pages = "627-634",
    publisher = "MARY ANN LIEBERT INC PUBL",
    issn = "1520-9156, 1557-8593",
    doi = "10.1089/dia.2019.0170",
    keywords = "Euglyca; Children and adolescents; Type 1 diabetes mellitus; Glycemic
control; Satisfaction; Mobile application",
    abstract = "Background: Euglyca is a mobile application which we developed for
children and adolescents suffering type 1 diabetes mellitus (T1DM) for
calculation of the appropriate insulin bolus dose by importing in the
equation carbohydrates, lipids, glucose levels, and personalized
parameters. Aim of this study is to evaluate the efficacy of this
application on patients' glycemic control and satisfaction. Subjects and
Methods: Eighty children and adolescents (aged 13.5 +/- 2.8 years old,
mean +/- standard deviation) with T1DM were included in the study and
were randomly and equally assigned in two groups. Patients were asked to
use Euglyca for the calculation of the bolus insulin dose in the E group
and to pursue their routine calculations in the C group (controls). At
baseline and at 3, 6, and 12 months following the initial visit,
glycated hemoglobin (HbA1c) values, percentages of hypoglycemias,
hyperglycemias, and normoglycemias were determined for each patient,
while Diabetes Treatment Satisfaction Questionnaire (DTSQ) was used to
assess patients' treatment satisfaction at baseline and at 6 and 12
months. Results: Children and adolescents in the E group had a
statistically significant decrease in HbA1c values and increase in
percentages of normoglycemias and DTSQ scores, in comparison to children
and adolescents in the C group. In the E group, a statistically
significant positive linear correlation was found between DTSQ score and
percentages of normoglycemias and a statistically significant negative
correlation between changes in percentages of normoglycemias (Delta
normoglycemias) and changes in HbA1c (Delta HbA1c). Conclusions: The use
of the mobile application Euglyca contributes to the improvement of
glycemic control and treatment satisfaction of children and adolescents
with T1DM."
}