@article{3187941,
    title = "THE IMPACT OF MANUAL THERAPY TECHNIQUES ON PAIN, DISABILITY AND IL-1B
LEVELS IN PATIENTS WITH CHRONIC CERVICAL PAIN",
    author = "Konstantinos, Zemadanis and Theodoros, Betsos and Anastasios, Philippou and and Michalis, Koutsilieris",
    journal = "INTERNATIONAL JOURNAL OF PHYSIOTHERAPY",
    year = "2019",
    volume = "6",
    number = "6",
    pages = "268-276",
    publisher = "IJPHY Publisher",
    doi = "10.15621/ijphy/2019/v6i6/190224",
    keywords = "manual therapy; chronic neck pain; cytokines",
    abstract = "Background: Chronic neck pain is a common musculoskeletal dysfunction,
and Manual Therapy is one of the effective treatment modalities, but
underlying mechanisms of action are unclear. The study's purpose was to
investigate the short-term effect of mobilization-manipulations on
patient's symptoms and to detect changes in the concentration of
inflammatory biomarker interleukin-1b.
Methods: Twenty-two patients aged 20-50 years with chronic neck pain,
randomly assigned into two groups. The study group received nine
sessions of a three-week Manual Therapy intervention. The control group
received SHAM Manual Therapy of the same dosage. Pain and functionality
measures conducted before and after the intervention via NPRS and NDI
scales, respectively. Blood samples collected at baseline, after the
first session and post-intervention, detecting IL-1 beta concentration,
using the corresponding ELISA kit. Mixed ANOVA statistical analysis
implemented for differences in the GROUP-TIME factors.
Results: There was a significant statistical interaction between factors
and significant main effects on pain, functionality, and IL-1 beta (p
<.05). IL-1 beta was statistically significant reduced (p <.05) at
second measurement for the study group, but not significantly reduced
(p>.05) between second and final measurement. No statistical
significance was found for the control group on any of the dependent
variables across measures.
Conclusion: Patients with chronic mechanical pain showed significant
pain and functionality improvement after manual therapy application. The
underlying mechanism of action seems to relate with a reduced IL-1b
concentration of reinforcing future research at relevant pain
biomarkers."
}